caa a22 4500 465737498 CHVBK 20180323111758.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02247131 doi (NATIONALLICENCE)springer-10.1007/BF02247131 Serenics fluprazine (DU 27716) and eltoprazine (DU 28853) enhance neophobic and emotional behaviour in mice [Elektronische Daten] [Guy Griebel, Martine Saffroy-Spittler, René Misslin, Elise Vogel, James Martin] Two tests designed to elicit responses to novelty and to aversive stimuli were used to study the effects of the serenics fluprazine and eltoprazine on the behaviour of male Swiss mice: a free exploratory test (fluprazine: 2.5, 5 and 10 mg/kg; eltoprazine: 2.5, 5, 10 and 15 mg/kg) and a two-box choice procedure (fluprazine: 1.25, 2.5, 5 and 7.5 mg/kg; eltoprazine: 2.5, 5, 7.5 and 10 mg/kg). Both drugs increased the neophobic reaction, as well as the avoidance of a brightly illuminated box. These effects closely resemble those of psychostimulant drugs such as methamphetamine and caffeine. It is hypothesized that the behavioural changes induced by these drugs may be due to a nonspecific increase of the emotional reactivity of animals. Springer-Verlag, 1990 Fluprazine nationallicence Eltoprazine nationallicence Serenics nationallicence Exploration nationallicence Locomotion nationallicence Rearing nationallicence Light/dark procedure nationallicence Anxiety nationallicence Emotionality nationallicence Mice nationallicence Griebel Guy Laboratoire de Psychophysiologie, 7 rue de l'Université, F-67000, Strasbourg, France aut Saffroy-Spittler Martine Laboratoire de Psychophysiologie, 7 rue de l'Université, F-67000, Strasbourg, France aut Misslin René Laboratoire de Psychophysiologie, 7 rue de l'Université, F-67000, Strasbourg, France aut Vogel Elise Laboratoire de Psychophysiologie, 7 rue de l'Université, F-67000, Strasbourg, France aut Martin James Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd., CH-4002, Basel, Switzerland aut Psychopharmacology Springer-Verlag 102/4(1990-12-01), 498-502 0033-3158 102:4<498 1990 102 213 https://doi.org/10.1007/BF02247131 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02247131 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Griebel Guy Laboratoire de Psychophysiologie, 7 rue de l'Université, F-67000, Strasbourg, France aut NATIONALLICENCE 700 1- Saffroy-Spittler Martine Laboratoire de Psychophysiologie, 7 rue de l'Université, F-67000, Strasbourg, France aut NATIONALLICENCE 700 1- Misslin René Laboratoire de Psychophysiologie, 7 rue de l'Université, F-67000, Strasbourg, France aut NATIONALLICENCE 700 1- Vogel Elise Laboratoire de Psychophysiologie, 7 rue de l'Université, F-67000, Strasbourg, France aut NATIONALLICENCE 700 1- Martin James Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd., CH-4002, Basel, Switzerland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/4(1990-12-01), 498-502 0033-3158 102:4<498 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer