caa a22 4500 46573751X CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245931 doi (NATIONALLICENCE)springer-10.1007/BF02245931 Interactions of naloxone with morphine, amphetamine and phencyclidine on fixed interval responding for intracranial self-stimulation in rats [Elektronische Daten] [Gerald Schaefer, Richard Michael] Rats were implanted with stimulating electrodes aimed at the medial forebrain bundle-lateral hypothalamus (MFB-LH) and were trained to lever-press for brain self-stimulation on a fixed interval: 60 s schedule of reinforcement. The effects of graded doses of naloxone (0.1-30 mg/kg), morphine (0.3-5.6 mg/kg), naloxone plus morphine,d-amphetamine (0.03-1.0 mg/kg), naloxone plusd-amphetamine, phencyclidine (0.3-5.6 mg/kg), and naloxone plus phencyclidine were tested. Naloxone produced a significant decrease in rates at 30 mg/kg. Naloxone (0.1-1.0 mg/kg) plus morphine blocked the dose-dependent decrease produced by morphine alone. In contrast, naloxone (1.0-10 mg/kg) plusd-amphetamine attenuated the graded increase in response rates produced byd-amphetamine. Naloxone (1.0-10 mg/kg) plus phencyclidine did not reliably change the increase in response rates produced by phencyclidine alone. The use of the fixed interval schedule of brain self-stimulation to study these drug interactions is novel, and further demonstrates that the highly reinforcing aspects of brain stimulation, known to be influenced by dopamine, may also be modulated by the endogenous opiate system. Springer-Verlag, 1990 Fixed interval: 60 s schedule nationallicence Intracranial self-stimulation nationallicence Naloxone nationallicence Morphine nationallicence d -Amphetamine nationallicence Phencyclidine nationallicence Schaefer Gerald Georgia Mental Health Institute, 1256 Briarcliff Road NE, 30306, Atlanta, GA, USA aut Michael Richard Department of Psychiatry, Emory University School of Medicine, 30322, Atlanta, GA, USA aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 263-268 0033-3158 102:2<263 1990 102 213 https://doi.org/10.1007/BF02245931 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245931 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schaefer Gerald Georgia Mental Health Institute, 1256 Briarcliff Road NE, 30306, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Michael Richard Department of Psychiatry, Emory University School of Medicine, 30322, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 263-268 0033-3158 102:2<263 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer