caa a22 4500 465737528 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245920 doi (NATIONALLICENCE)springer-10.1007/BF02245920 Self-administration in baboons and the discriminative stimulus effects in rats of bupropion, nomifensine, diclofensine and imipramine [Elektronische Daten] [R. Lamb, Roland Griffiths] The behavioral effects of the antidepressants nomifensine, diclofensine, bupropion, and imipramine were examined using a cocaine substitution drug self-administration procedure in baboons and a cocaine drug discrimination procedure in rats. Intravenous self-administration of the antidepressants was examined in baboons under conditions in which baseline responding was maintained by intravenous injections of cocaine HCl (0.32 mg/kg/injection). Drug was available under a fixed-ratio 80-response or 160-response schedule of intravenous injection. Each drug injection was followed by a 3-h time-out allowing a maximum of eight injections per day. The antidepressants or their vehicles were substituted for cocaine for a period of 15 days, followed by a return to the cocaine baseline. Nomifensine, diclofensine, and bupropion all maintained self-administration behavior at levels above those maintained by their respective vehicles. Some doses of nomifensine, diclofensine, and bupropion maintained levels of behavior similar to those maintained under baseline cocaine conditions. High doses of imipramine maintained levels of behavior above those maintained by its vehicle, but the amount of behavior maintained under these conditions was extremely small. In a second experiment rats were trained to discriminate 32 µmol/kg cocaine (IP 10 min presession) from no drug in a two-lever food reinforced drug discrimination procedure in which responding on one lever was reinforced following ten consecutive responses when the session was preceded by cocaine administration, while responding on the other lever was similarly reinforced in the absence of cocaine pretreatment. Cocaine, nomifensine, diclofensine, and bupropion all dose-dependently occasioned cocaine-appropriate responding. Imipramine did not occasion cocaine-appropriate responding over a range of behaviorally active doses. Springer-Verlag, 1990 Self-administration nationallicence Drug discrimination nationallicence Nomifensine nationallicence Bupropion nationallicence Diclofensine nationallicence Imipramine nationallicence Cocaine nationallicence Drug abuse nationallicence Baboon nationallicence Rat nationallicence Lamb R. Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, The Johns Hopkins University School of Medicine, 21225, Baltimore, MD, USA aut Griffiths Roland Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, The Johns Hopkins University School of Medicine, 21225, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 183-190 0033-3158 102:2<183 1990 102 213 https://doi.org/10.1007/BF02245920 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245920 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lamb R. Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, The Johns Hopkins University School of Medicine, 21225, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Griffiths Roland Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, The Johns Hopkins University School of Medicine, 21225, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 183-190 0033-3158 102:2<183 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer