caa a22 4500 465737560 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245934 doi (NATIONALLICENCE)springer-10.1007/BF02245934 Pimozide does not impair sweetness discrimination [Elektronische Daten] [Paul Willner, Mariusz Papp, Gavin Phillips, Mary Maleeh, Richard Muscat] In an initial experiment pimozide decreased preference for a weak sucrose solution but increased preference for a strong solution on the descending limb of the concentration-intake function. As these effects resemble those of dilution, we therefore investigated whether pimozide decreases the perceived intensity of sweet stimuli. Rats were trained to perform a conditional discrimination in a T-maze. A correct response was rewarded by access to a 10% sucrose solution; an incorrect response was punished by confinement in the non-rewarded arm. In the first part of this experiment the discriminative stimulus, located at the choice point of the T-maze, was either water or sucrose, initially a 10% solution, but reduced gradually to 0.0003%. In the second part of the experiment, the discriminative stimulus was either 1% sucrose or a weaker solution, which was initially 0.0001% then raised gradually to 0.5%. Performance fell below 75% accuracy at 0 versus 0.0012% and at 1% versus 0.1%. Pimozide (0.5 mg/kg) administered at these (and other) levels of difficulty decreased running speed but had no effect on discrimination accuracy. As pimozide did not affect either the threshold for sweetness perception or the discrimination of a just noticeable difference, the decreased responsiveness of neuroleptic-treated rats to sweet rewards cannot be explained by a change in the perception of sweetness. Springer-Verlag, 1990 Sucrose nationallicence Preference nationallicence Discrimination nationallicence 2-Bottle test nationallicence T-maze nationallicence Pimozide nationallicence Rats nationallicence Willner Paul Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Papp Mariusz Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Phillips Gavin Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Maleeh Mary Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Muscat Richard Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 278-282 0033-3158 102:2<278 1990 102 213 https://doi.org/10.1007/BF02245934 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245934 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Willner Paul Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Papp Mariusz Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Phillips Gavin Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Maleeh Mary Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Muscat Richard Department of Psychology, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 278-282 0033-3158 102:2<278 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer