caa a22 4500 465737579 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245927 doi (NATIONALLICENCE)springer-10.1007/BF02245927 Differential effects of catecholamine antagonists on ethanol-induced excitation in mice [Elektronische Daten] [Ulrike Koechling, Brian Smith, Zalman Amit] Catecholamine antagonists were assessed for their effects on ethanol-induced motor excitation. Motor excitation was measured in male Swiss-Webster mice using an open-field apparatus. Mice were treated with several doses of ethanol and at each dose, mice were pretreated with pimozide, a dopamine D2 antagonist, Schering 23390, a dopamine D1 antagonist, phenoxybenzamine, a noradrenergic alpha-1 antagonist, or yohimbine, a noradrenergic alpha-2 antagonist. Each mouse was subjected to only one dose regimen, and all injections were given IP. Ethanol produced an increase in locomotor activity. The degree to which pimozide attenuated ethanol excitation decreased with increasing ethanol dosage. At the highest dose of ethanol, pimozide increased ethanol excitation. Schering 23390 attenuated ethanol-induced excitation only at doses which affected motor activity per se. Phenoxybenzamine produced a dose-dependent reduction in ethanol excitation. Yohimbine had its greatest effects at the medium dose (4.0 mg/kg). These observations seem to indicate a role for both the dopamine D2 receptor and the noradrenergic alpha-1 receptor in ethanol-induced motor excitation. Springer-Verlag, 1990 Ethanol nationallicence Dopamine nationallicence Norepinephrine nationallicence Locomotor activity nationallicence Drug antagonists nationallicence Koechling Ulrike Center for Studies in Behavioral Neurobiology, Concordia University, 1455 de Maisonneuve Boulevard W., H-1013, H3G 1M8, Montreal, Quebec, Canada aut Smith Brian Center for Studies in Behavioral Neurobiology, Concordia University, 1455 de Maisonneuve Boulevard W., H-1013, H3G 1M8, Montreal, Quebec, Canada aut Amit Zalman Center for Studies in Behavioral Neurobiology, Concordia University, 1455 de Maisonneuve Boulevard W., H-1013, H3G 1M8, Montreal, Quebec, Canada aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 234-238 0033-3158 102:2<234 1990 102 213 https://doi.org/10.1007/BF02245927 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245927 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koechling Ulrike Center for Studies in Behavioral Neurobiology, Concordia University, 1455 de Maisonneuve Boulevard W., H-1013, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Smith Brian Center for Studies in Behavioral Neurobiology, Concordia University, 1455 de Maisonneuve Boulevard W., H-1013, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Amit Zalman Center for Studies in Behavioral Neurobiology, Concordia University, 1455 de Maisonneuve Boulevard W., H-1013, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 234-238 0033-3158 102:2<234 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer