caa a22 4500 465737587 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245919 doi (NATIONALLICENCE)springer-10.1007/BF02245919 Metabolic mapping of the effects of intravenous methamphetamine administration in freely moving rats [Elektronische Daten] [Francesco Pontieri, Alison Crane, Lewis Seiden, Mark Kleven, Linda Porrino] The 2-[14C]deoxyglucose method was used to examine the effects of acute intravenous administration of methamphetamine (0.5-2.5 mg/kg) on rates of local cerebral glucose utilization in freely-moving rats. These effects were correlated with the effects of methamphetamine on locomotor activity assessed simultaneously in the same animals. Methamphetamine administration resulted in widespread dose-dependent increases in glucose utilization within structures of the extrapyramidal motor system. Rates of glucose utilization were positively correlated with locomotor activity in the globus pallidus, substantia nigra reticulata, entopeduncular nucleus, subthalamic nucleus, and the lateral cerebellar cortex. In contrast, within the limbic system alterations in metabolic activity were smaller and more selective. Glucose utilization was increased in the nucleus accumbens at all doses tested, but alterations in glucose utilization in the ventral tegmental area, amygdala, and anterior cingulate were observed only at the highest doses of methamphetamine tested. Significant increases in rates of glucose metabolism were also found in the substantia nigra compacta and in the median and dorsal raphe nuclei. Dopamine and serotonin are depleted in these regions, as well as in the ventral tegmental area where glucose utilization was also increased, following chronic treatment with high doses of methamphetamine. These changes in glucose utilization may be indicative of disturbances in the biochemical processes involved in the neurotoxic effects of methamphetamine. Springer-Verlag, 1990 Methamphetamine nationallicence Rats nationallicence Glucose utilization nationallicence Pontieri Francesco Department of Health and Human Services, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Public Health Service, 20892, Bethesda, MD, USA aut Crane Alison Department of Health and Human Services, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Public Health Service, 20892, Bethesda, MD, USA aut Seiden Lewis Department of Pharmacological and Physiological Sciences, University of Chicago, 60637, Chicago, IL, USA aut Kleven Mark Department of Pharmacological and Physiological Sciences, University of Chicago, 60637, Chicago, IL, USA aut Porrino Linda Unit on Brain Imaging, National Institute of Neurological Disorders and Stroke, 9000 Rockville Pike, Building 10, Room 5N-214, 20892, Bethesda, MD, USA aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 175-182 0033-3158 102:2<175 1990 102 213 https://doi.org/10.1007/BF02245919 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245919 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pontieri Francesco Department of Health and Human Services, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Public Health Service, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Crane Alison Department of Health and Human Services, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Public Health Service, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Seiden Lewis Department of Pharmacological and Physiological Sciences, University of Chicago, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Kleven Mark Department of Pharmacological and Physiological Sciences, University of Chicago, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Porrino Linda Unit on Brain Imaging, National Institute of Neurological Disorders and Stroke, 9000 Rockville Pike, Building 10, Room 5N-214, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 175-182 0033-3158 102:2<175 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer