caa a22 4500 465737609 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245933 doi (NATIONALLICENCE)springer-10.1007/BF02245933 Behavioural analysis of the anorectic effects of fluoxetine and fenfluramine [Elektronische Daten] [Paul Willner, Joan McGuirk, Gavin Phillips, Richard Muscat] Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later superceded by resting. This "behavioural satiety sequence” was advanced by fluoxetine, but disrupted bydl-fenfluramine, which suppressed post-prandial resting, even at sub-anorectic doses. Fluoxetine also elicited resting behaviour following water drinking. However, this did not appear to be a non-specific sedative effect, since fluoxetine increased post-prandial grooming. In rats performing on random interval schedules of food reinforcement, fluoxetine caused proportionally greater decreases in responding on a reinforcement-lean schedule (RI-300s), as compared to a reinforcement-rich schedule (RI-7.5s); this effect is similar to that of a reduction in level of food deprivation. By contrast, fenfluramine reduced responding equally on both schedules. In both paradigms, the effects of fluoxetine were compatible with an increase in postprandial satiety, but the effects of fenfluramine were not. Springer-Verlag, 1990 Feeding nationallicence Fluoxetine nationallicence Fenfluramine nationallicence Behavioural satiety sequence nationallicence Post-prandial resting nationallicence Matching law nationallicence Random interval reinforcement schedules nationallicence Rat nationallicence Willner Paul Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut McGuirk Joan Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Phillips Gavin Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Muscat Richard Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 273-277 0033-3158 102:2<273 1990 102 213 https://doi.org/10.1007/BF02245933 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245933 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Willner Paul Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- McGuirk Joan Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Phillips Gavin Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Muscat Richard Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 273-277 0033-3158 102:2<273 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer