caa a22 4500 465737625 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245932 doi (NATIONALLICENCE)springer-10.1007/BF02245932 Silverman Peter Department of Psychiatry-MSI, University of Texas Medical School, 77030, Houston, TX, USA aut Cocaine and local anesthetics: Stimulant activity in rats with nigral lesions [Elektronische Daten] [Peter Silverman] Cocaine and several other local anesthetics were tested for their ability to induce rotational behavior in rats with unilateral 6-hydroxydopamine lesions of substantia nigra. Acute administration of bupivacaine, chloroprocaine, etidocaine, lidocaine, mepivacaine, procaine or tetracaine failed to induce active rotation in this sensitive assay of dopamine agonist activity. On the other hand, cocaine or dimethocaine treatment induced active rotation directed ipsilaterally to the lesioned side, indicating indirect dopamine agonist activity. Repeated administration of cocaine or dimethocaine at 1-week intervals resulted in increased rotational response (i.e., sensitization) while there was no suggestion of sensitization or induction of rotational behavior after weekly repeated administration of procaine or tetracaine. Daily administration of mepivacaine, procaine or tetracaine for 5 days also failed to induce rotation. Dimethocaine thus was found similar to cocaine and different from the other local anesthetics tested both in terms of frank stimulant activity and development of sensitization upon repeated administration. Springer-Verlag, 1990 Dopamine nationallicence Rotational behavior nationallicence 6-Hydroxydopamine lesions nationallicence Sensitization nationallicence Bupivacaine nationallicence Chloroprocaine nationallicence Dimethocaine nationallicence Etidocaine nationallicence Lidocaine nationallicence Mepivacaine nationallicence Procaine nationallicence Tetracaine nationallicence Psychopharmacology Springer-Verlag 102/2(1990-10-01), 269-272 0033-3158 102:2<269 1990 102 213 https://doi.org/10.1007/BF02245932 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245932 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Silverman Peter Department of Psychiatry-MSI, University of Texas Medical School, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 269-272 0033-3158 102:2<269 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer