caa a22 4500 465737633 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245924 doi (NATIONALLICENCE)springer-10.1007/BF02245924 Glucose modulation of skin temperature responses during morphine withdrawal in the rat [Elektronische Daten] [J. Simpkins, M. Katovich, W. Millard] Studies were undertaken to determine the effects of acute alterations in plasma glucose levels on the tail skin temperature (TST) response of morphine-dependent rats to naloxone-precipitated withdrawal. In morphine-dependent rats, treatment with dextrose at doses of 0.5 or 2.5 g/kg did not alter the normal 6.0±0.3° C TST response to naloxone. However, treatment with 5, 10 or 20 g dextrose/kg, which increased plasma glucose to 250 mg/dl or greater, blocked the TST response during morphine withdrawal. In contrast, an IV injection of 2.5 IU insulin (Na-porcine)/kg, which reduced plasma glucose for 2 h, caused a delayed TST response of 4.7±0.4° C in control rats and exaggerated the TST response normally observed in morphine-dependent rats treated with naloxone. Collectively, these data indicate that acute hyperglycemia can attenuate and hypoglycemia can enhance the skin vasodilation which accompanies precipitated morphine withdrawal. In view of our observation that naloxone-precipitated morphine withdrawal caused a marked increasee in blood glucose, the sympathetic activation associated with opiate withdrawal may be intended to elevate blood glucose and thereby limit the manifestation of the withdrawal response. Springer-Verlag, 1990 Glucose nationallicence Morphine nationallicence Opiates nationallicence Withdrawal nationallicence Temperature regulation nationallicence Simpkins J. Department of Pharmacodynamics, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Box J-487, 32610, Gainesville, FL, USA aut Katovich M. Department of Pharmacodynamics, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Box J-487, 32610, Gainesville, FL, USA aut Millard W. Department of Pharmacodynamics, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Box J-487, 32610, Gainesville, FL, USA aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 213-220 0033-3158 102:2<213 1990 102 213 https://doi.org/10.1007/BF02245924 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245924 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Simpkins J. Department of Pharmacodynamics, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Box J-487, 32610, Gainesville, FL, USA aut NATIONALLICENCE 700 1- Katovich M. Department of Pharmacodynamics, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Box J-487, 32610, Gainesville, FL, USA aut NATIONALLICENCE 700 1- Millard W. Department of Pharmacodynamics, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Box J-487, 32610, Gainesville, FL, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 213-220 0033-3158 102:2<213 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer