caa a22 4500 46573765X CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245923 doi (NATIONALLICENCE)springer-10.1007/BF02245923 Acute tolerance to ethanol using drug discrimination and open-field procedures in rats [Elektronische Daten] [Arto Hiltunen, Torbjörn Järbe] This study examined the phenomenon of acute tolerance to ethanol (ETOH) using drug discrimination learning (DDL), and open-field (OF) procedures. In DDL, rats were trained to discriminate between ETOH (1.2 g/kg) and saline. Doses of ETOH lower (0.6 and 0.9 g/kg), or higher (1.8 and 2.4 g/kg) than the training dose were tested to examine possible influence of ETOH pretreatment doses on the expression of acute tolerance. To assess concentrations of ETOH in the organism, a rebreathed air procedure was used. Equal concentrations after different ETOH doses were achieved by postponing the tests until sufficient time had elapsed. Only doses of ETOH higher than the training dose produced acute tolerance in the DDL procedure. For the response-time data no acute tolerance was observed. In the OF experiment, the occurrence of acute tolerance was examined for different spontaneous behaviours in drug-naive animals. At equal ETOH concentrations, the group examined during the descending phase of intoxication (1.8 g/kg, 60 min post-injection), reared significantly more than the group tested during the ascending phase (1.5 g/kg, 10 min post-injection). Other OF behaviours did not differ significantly between the two time intervals. Thus, it is suggested that acute tolerance is seen both in ETOH naive and in ETOH pre-exposed rats. However, in DDL acute tolerance was observed only when doses higher than the training dose of ETOH were evaluated. Springer-Verlag, 1990 Acute tolerance nationallicence ETOH nationallicence Drug discrimination nationallicence Open-field nationallicence Rats nationallicence Hiltunen Arto Department of Clinical Psychology, University of Uppsala, Box 1225, S-751 42, Uppsala, Sweden aut Järbe Torbjörn Department of Psychology, University of Uppsala, Box 1854, S-751 48, Uppsala, Sweden aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 207-212 0033-3158 102:2<207 1990 102 213 https://doi.org/10.1007/BF02245923 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245923 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hiltunen Arto Department of Clinical Psychology, University of Uppsala, Box 1225, S-751 42, Uppsala, Sweden aut NATIONALLICENCE 700 1- Järbe Torbjörn Department of Psychology, University of Uppsala, Box 1854, S-751 48, Uppsala, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 207-212 0033-3158 102:2<207 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer