caa a22 4500 465737668 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02245928 doi (NATIONALLICENCE)springer-10.1007/BF02245928 Action of chlormethiazole in a model of ethanol withdrawal [Elektronische Daten] [A. Green, E. Davies, H. Little, M. Whittington, A. Cross] Mice withdrawn from exposure for 14 days to ethanol inhalation showed the expected signs of ethanol withdrawal including convulsive behaviour. Injection of chlormethiazole (100 mg/kg) 5 h after the start of withdrawal, at the time that the convulsive behaviour was near maximal, resulted in the virtual disappearance of the withdrawal — induced behaviour within 30 min, with its reappearance by 60 min. A dose of chlormethiazole of 40 mg/kg was without effect. The time course of the effect of chlormethiazole (100 mg/kg) in the withdrawal test was similar to its effect in raising seizure threshold and decreasing locomotor activity. Chlormethiazole did not alter in vitro binding of [3H]-PN 200-110 to the dihydropyridine sensitive Ca2+ channel. Chlormethiazole, a drug used clinically to treat ethanol withdrawal, has therefore been shown to be effective in this animal model of withdrawal. Dihydropyridine calcium antagonists are also active in the model but chlormethiazole is likely to work by a different mechanism and it is suggested that this may be by increasing GABAergic function. Springer-Verlag, 1990 Chlormethiazole nationallicence Alcohol withdrawal nationallicence Convulsions nationallicence Locomotor activity nationallicence Dihydropyridines nationallicence Green A. Astra Neuroscience Research Unit, 1 Wakefield Street, WC1N 1PJ, London, UK aut Davies E. Astra Neuroscience Research Unit, 1 Wakefield Street, WC1N 1PJ, London, UK aut Little H. Department of Pharmacology, The Medical School, University Walk, BS8 1TD, Bristol, UK aut Whittington M. Department of Pharmacology, The Medical School, University Walk, BS8 1TD, Bristol, UK aut Cross A. Astra Neuroscience Research Unit, 1 Wakefield Street, WC1N 1PJ, London, UK aut Psychopharmacology Springer-Verlag 102/2(1990-10-01), 239-242 0033-3158 102:2<239 1990 102 213 https://doi.org/10.1007/BF02245928 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245928 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Green A. Astra Neuroscience Research Unit, 1 Wakefield Street, WC1N 1PJ, London, UK aut NATIONALLICENCE 700 1- Davies E. Astra Neuroscience Research Unit, 1 Wakefield Street, WC1N 1PJ, London, UK aut NATIONALLICENCE 700 1- Little H. Department of Pharmacology, The Medical School, University Walk, BS8 1TD, Bristol, UK aut NATIONALLICENCE 700 1- Whittington M. Department of Pharmacology, The Medical School, University Walk, BS8 1TD, Bristol, UK aut NATIONALLICENCE 700 1- Cross A. Astra Neuroscience Research Unit, 1 Wakefield Street, WC1N 1PJ, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 102/2(1990-10-01), 239-242 0033-3158 102:2<239 1990 102 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer