caa a22 4500 465737706 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02253723 doi (NATIONALLICENCE)springer-10.1007/BF02253723 A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation [Elektronische Daten] [J. Deakin, I. Pennell, A. Upadhyaya, R. Lofthouse] To investigate whether depression is a consequence of disturbed function in 5HT systems, neuroendocrine responses to infusions of the 5HT precursorl-tryptophan (LTP) were studied in patients and controls. After an overnight fast and 60 min bed rest, a solution of LTP (10 g/l) was infused intravenously to a dose of 100 mg/kg over 30 min. Circulating growth hormone (GH), prolactin (PRL), cortisol and tryptophan concentrations were followed from 60 min pre-infusion to 60 min post-infusion. GH responses were attenuated in 23 major depressives (DSM-III) compared with 22 controls and were almost absent in endogenous depressives (New-castle criteria). PRL responses were normal in depressives who had lost more than 3 kg body weight but attenuated in those who had not. GH and PRL responses did not correlate with each other. Reduced basal tryptophan concentrations and more rapid tryptophan clearance were observed in the depressives, but there were no correlations with GH or PRL responses. However, basal cortisol concentrations, which were raised in depressives with chronic psychosocial difficulties, were strongly and inversely predictive of PRL responses in depressives and controls. Blunted GH and PRL responses to LTP appear to be distinct abnormalities in depression which may relate to two processes; (1), an endogenous mechanism indicated by reduced GH responses, and (2), an impairment in 5HT systems, indicated by blunted PRL responses and perhaps caused by raised circulating cortisol or reduced tryptophan concentrations. Springer-Verlag, 1990 5HT nationallicence Prolactin nationallicence Growth hormone nationallicence Cortisol nationallicence Depression nationallicence Deakin J. Department of Psychiatry, University Hospital of South Manchester, West Didsbury, M20 8LR, Manchester, UK aut Pennell I. Department of Psychiatry, University Hospital of South Manchester, West Didsbury, M20 8LR, Manchester, UK aut Upadhyaya A. Department of Psychiatry, University Hospital of South Manchester, West Didsbury, M20 8LR, Manchester, UK aut Lofthouse R. CRC Department of Psychiatry, Northwick Park Hospital, Watford Road, Harrow, Middlesex, UK aut Psychopharmacology Springer-Verlag 101/1(1990-05-01), 85-92 0033-3158 101:1<85 1990 101 213 https://doi.org/10.1007/BF02253723 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253723 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Deakin J. Department of Psychiatry, University Hospital of South Manchester, West Didsbury, M20 8LR, Manchester, UK aut NATIONALLICENCE 700 1- Pennell I. Department of Psychiatry, University Hospital of South Manchester, West Didsbury, M20 8LR, Manchester, UK aut NATIONALLICENCE 700 1- Upadhyaya A. Department of Psychiatry, University Hospital of South Manchester, West Didsbury, M20 8LR, Manchester, UK aut NATIONALLICENCE 700 1- Lofthouse R. CRC Department of Psychiatry, Northwick Park Hospital, Watford Road, Harrow, Middlesex, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/1(1990-05-01), 85-92 0033-3158 101:1<85 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer