caa a22 4500 465737722 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02253711 doi (NATIONALLICENCE)springer-10.1007/BF02253711 Cocaine produces locomotor stimulation in SS but not LS mice: Relationship to dopaminergic function [Elektronische Daten] [Frank George, Mary Ritz] Cocaine produces several behavioral effects, most notably locomotor stimulation. While low doses of cocaine have been shown to decrease locomotor activity, moderate to high doses in the range of 5-50 mg/kg usually produce a marked increase in locomotor activity in rodents. This study examined the effects of a range of cocaine doses, 1-75 mg/kg, on locomotor activity in LS/Ibg (LS) and SS/Ibg (SS) mice. At the lowest doses, activity was depressed in both lines, but to a greater extent in LS mice. As the dose of cocaine was increased, activity returned to baseline, and at the highest doses, increases in locomotor activity were found, but only in SS mice. In LS mice, cocaine was ineffective in increasing locomotor activity at any of the doses tested. Since striatal dopaminergic neurons influence locomotor activity, we also assessed ligand affinity and receptor density of dopamine transporters and dopaminergic D1 and D2 receptors in striatal tissue obtained from these two selected lines. No differences in these receptor binding parameters were found. However, because of their anomalous locomotor response to cocaine, LS mice may prove to be a valuable tool in increasing our understanding of those sites which mediate specific effects of cocaine. Springer-Verlag, 1990 Long Sleep mice nationallicence Short Sleep mice nationallicence Locomotor activity nationallicence Dopamine nationallicence Cocaine nationallicence George Frank Behavioral and Biochemical Genetics Laboratory, National Institute on Drug Abuse, Addiction Research Center, Box 5180, 21224, Baltimore, MD, USA aut Ritz Mary Behavioral and Biochemical Genetics Laboratory, National Institute on Drug Abuse, Addiction Research Center, Box 5180, 21224, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 101/1(1990-05-01), 18-22 0033-3158 101:1<18 1990 101 213 https://doi.org/10.1007/BF02253711 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253711 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- George Frank Behavioral and Biochemical Genetics Laboratory, National Institute on Drug Abuse, Addiction Research Center, Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Ritz Mary Behavioral and Biochemical Genetics Laboratory, National Institute on Drug Abuse, Addiction Research Center, Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/1(1990-05-01), 18-22 0033-3158 101:1<18 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer