caa a22 4500 465737730 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02253721 doi (NATIONALLICENCE)springer-10.1007/BF02253721 Changes in GABA content and turnover in discrete regions of rat brain after systemic administration of caerulein [Elektronische Daten] [Kaoru Nakamura, Takashi Matsumoto, Makoto Hirano, Hideyuki Uchimura] The effects of systemically injected caerulein, a cholecystokinin octapeptide analogue, on GABA content and turnover have been studied in various regions of rat brain. Caerulein decreased GABA levels in the nucleus accumbens, tuberculum olfactorium and substantia nigra and diminished GABA turnover rates in the striatum, nucleus accumbens and substantia nigra, as estimated from the rate of GABA accumulation after inhibition of GABA transaminase by aminooxyacetic acid (AOAA). These results indicate the effect of caerulein on the utilization of GABA in specific cerebral regions and suggest that the GABAergic system is involved in the mechanism of action of peripherally administered caerulein. Springer-Verlag, 1990 Caerulein nationallicence GABA nationallicence GC-MS nationallicence Nakamura Kaoru Department of Neuropsychiatry, Faculty of Medicine, Kyusyu University, Maidashi, Higashiku, 812, Fukuoka, Japan aut Matsumoto Takashi Laboratory of Neurochemistry, Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki Saga, Japan aut Hirano Makoto Laboratory of Neurochemistry, Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki Saga, Japan aut Uchimura Hideyuki Laboratory of Neurochemistry, Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki Saga, Japan aut Psychopharmacology Springer-Verlag 101/1(1990-05-01), 73-76 0033-3158 101:1<73 1990 101 213 https://doi.org/10.1007/BF02253721 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253721 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakamura Kaoru Department of Neuropsychiatry, Faculty of Medicine, Kyusyu University, Maidashi, Higashiku, 812, Fukuoka, Japan aut NATIONALLICENCE 700 1- Matsumoto Takashi Laboratory of Neurochemistry, Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki Saga, Japan aut NATIONALLICENCE 700 1- Hirano Makoto Laboratory of Neurochemistry, Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki Saga, Japan aut NATIONALLICENCE 700 1- Uchimura Hideyuki Laboratory of Neurochemistry, Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, 842-01, Kanzaki Saga, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/1(1990-05-01), 73-76 0033-3158 101:1<73 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer