caa a22 4500 465737749 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02253714 doi (NATIONALLICENCE)springer-10.1007/BF02253714 Influences of peripheral adrenocorticotropin 1-39 (ACTH) and human corticotropin releasing hormone (h-CRH) on human auditory evoked potentials (AEP) [Elektronische Daten] [J. Born, B. Bathelt, R. Pietrowsky, P. Pauschinger, H. Fehm] Hormones of the hypothalamus-pituitary-adrenal (HPA) axis have been considered to form part of an efferent humoral system modulating central nervous stimulus processing. The present experiments were designed to compare the effects of iv bolus administrations of placebo, porcine ACTH 1-39 (1.5 U) and h-CRH (25 µg) on auditory evoked potentials (AEPs) in healthy men. Also, cardiovascular parameters, cortisol and self-reported mood were assessed. ACTH significantly reduced the amplitude of the N1 component of the AEP; P1 and P2 remained unchanged. The selective reduction of N1 amplitude defies an interpretation of the changes in terms of a reduced stimulus-induced cortical arousal following ACTH; the ACTH-induced changes may rather indicate an influence on frontocortical functions of directing attention. The effect of ACTH on N1 cannot be attributed to its adrenocorticotropic action or to cardiovascular changes, but appears to represent an intrinsic extraadrenal influence of the hormone. The data do not provide evidence for effects of h-CRH on central nervous stimulus processing in humans, after peripheral administration. Springer-Verlag, 1990 Adrenocorticotropin (ACTH) nationallicence Corticotropin releasing hormone (h-CRH) nationallicence Central nervous effects nationallicence Human nationallicence Auditory evoked potential (AEP) nationallicence Mood nationallicence Born J. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut Bathelt B. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut Pietrowsky R. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut Pauschinger P. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut Fehm H. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut Psychopharmacology Springer-Verlag 101/1(1990-05-01), 34-38 0033-3158 101:1<34 1990 101 213 https://doi.org/10.1007/BF02253714 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253714 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Born J. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut NATIONALLICENCE 700 1- Bathelt B. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut NATIONALLICENCE 700 1- Pietrowsky R. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut NATIONALLICENCE 700 1- Pauschinger P. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut NATIONALLICENCE 700 1- Fehm H. Angewandte Physiologie, Universität Ulm, OE, D-7900, Ulm, Federal Republic of Germany aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/1(1990-05-01), 34-38 0033-3158 101:1<34 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer