caa a22 4500 46573779X CHVBK 20180323111759.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02253713 doi (NATIONALLICENCE)springer-10.1007/BF02253713 Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropics, scopolamine and electroconvulsive shock [Elektronische Daten] [Jiro Itoh, Toshitaka Nabeshima, Tsutomu Kameyama] An elevated plus-maze consisting of two open and two enclosed arms was employed for an evaluation of memory in mice. Mice in the plus-maze escaped from the open arm to the enclosed arm because mice apparently dislike open and high spaces. The time it took for the mice to move from the open arm to the enclosed arm (transfer latency) was recorded. The transfer latency after the 2nd day was significantly shorter than that on the 1st day when it was recorded at a rate of one trial a day for 5 days. The transfer latency on the 2nd day was significantly prolonged in the mice administered electroconvulsive shock (300 V, 1 s) or scopolamine (20 µg, ICV) immediately after the first trial compared to the transfer latency in the control group. The prolongation of transfer latency in the mice administered an electroconvulsive shock was reversed by pretreatment with aniracetam (20 mg/kg, PO), but not tacrine and physostigmine. The prolongation of transfer latency in the mice administered scopolamine was reversed by pretreatment with aniracetam (10 and 20 mg/kg, PO) tacrine (1 and 3 mg/kg, PO), or physostigmine (0.025-0.2 mg/kg, IP). These results suggest that transfer latency may be one of the parameters of learning and memory. Springer-Verlag, 1990 Memory nationallicence Elevated plus-maze nationallicence Aniracetam nationallicence Tacrine (tetrahydroaminoacridine) nationallicence Scopolamine nationallicence Itoh Jiro Dept. Hospital Pharmacy, Nagoya University, School of Medicine, 466, Nagoya, Japan aut Nabeshima Toshitaka Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, 468, Nagoya, Japan aut Kameyama Tsutomu Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, 468, Nagoya, Japan aut Psychopharmacology Springer-Verlag 101/1(1990-05-01), 27-33 0033-3158 101:1<27 1990 101 213 https://doi.org/10.1007/BF02253713 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253713 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Itoh Jiro Dept. Hospital Pharmacy, Nagoya University, School of Medicine, 466, Nagoya, Japan aut NATIONALLICENCE 700 1- Nabeshima Toshitaka Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, 468, Nagoya, Japan aut NATIONALLICENCE 700 1- Kameyama Tsutomu Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, 468, Nagoya, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/1(1990-05-01), 27-33 0033-3158 101:1<27 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer