caa a22 4500 465737811 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02253729 doi (NATIONALLICENCE)springer-10.1007/BF02253729 Schechter Martin Department of Pharmacology, Northeastern Ohio Universities College of Medicine, 44272, Rootstown, OH, USA aut Rats become acutely tolerant to cathine after amphetamine or cathinone administration [Elektronische Daten] [Martin Schechter] The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kgd-amphetamine or 0.8 mg/kgl-cathinone to generalize to 2.4-6.0 mg/kg of the active cathinone metabolited-norpseudoephedrine, also known as cathine. When tested 24 h after vehicle administration, cathine generalized in a dose-related fashion in rats (n=6) trained with cathinone (ED50=3.03 mg/kg) and in rats (n=8) trained with amphetamine (ED50=2.93 mg/kg). In contrast, when cathine was tested 24 h after the administration of either amphetamine or cathinone, it produced significantly decreased discriminative performance. The possibility that this acute tolerance may have been produced by release, and subsequent depletion, of brain dopamine was tested by pretreating rats with the dopamine release inhibitor CGS 10746B. When CGS 10746B was administered prior to cathinone it significantly decreased cathinone discrimination. In addition, acute tolerance to cathine at 24 h after vehicle-cathinone co-administration was reversed when cathine was tested 24 h after CGS 10746B-cathinone co-administration. The results suggest that cathinone-produced discriminative stimulus, as well as the acute tolerance to cathine, may be dopaminergically mediated. Springer-Verlag, 1990 Cathinone nationallicence Amphetamine nationallicence Cathine nationallicence Drug discrimination nationallicence Dopamine nationallicence CGS 10746B nationallicence Psychopharmacology Springer-Verlag 101/1(1990-05-01), 126-131 0033-3158 101:1<126 1990 101 213 https://doi.org/10.1007/BF02253729 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253729 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Schechter Martin Department of Pharmacology, Northeastern Ohio Universities College of Medicine, 44272, Rootstown, OH, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/1(1990-05-01), 126-131 0033-3158 101:1<126 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer