caa a22 4500 465737838 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02253731 doi (NATIONALLICENCE)springer-10.1007/BF02253731 Control of food intake by kainate/quisqualate receptors in the median raphe nucleus [Elektronische Daten] [David Wirtshafter, Joseph Krebs] In previous studies we have reported that increases in food and water intake can be produced by microinjections of both NMDA selective and broad spectrum excitatory amino acid antagonists into the median raphe nucleus (MR). In the current experiments we examined the influence of kainate/quisqualate receptors in the MR on ingestive behavior. The consumption of food and water by deprived rats could be suppressed by intra-MR microinjections of the excitatory amino acid agonists kainic acid (5-10 ng in 0.5 µl vehicle) and quisqualic acid (125-500 ng). Conversely, intra-raphe injections of the kainate/quisqualate receptor antagonists pBB-PZDA (1.25-2.5 µg) and GAMS (10-20 µg) elicited feeding in nondeprived animals. pBB-PZDA was more potent in eliciting ingestive behavior than was the selective NMDA antagonist 2-amino-6-phosphonohexanoic acid, suggesting that the effects of pBB-PZDA were not mediated through the NMDA receptor. The current findings suggest that ingestive behaviors are tonically inhibited by excitatory amino acids acting at kainate/quisqualate receptors in the vicinity of the MR. Springer-Verlag, 1990 Food intake nationallicence Median raphe nucleus nationallicence Kainate nationallicence Quisqualate nationallicence Receptors nationallicence Wirtshafter David Department of Psychology and Committee on Neuroscience, University of Illinois at Chicago, Box 4348, 60680, Chicago, Il, USA aut Krebs Joseph Department of Psychology and Committee on Neuroscience, University of Illinois at Chicago, Box 4348, 60680, Chicago, Il, USA aut Psychopharmacology Springer-Verlag 101/1(1990-05-01), 137-141 0033-3158 101:1<137 1990 101 213 https://doi.org/10.1007/BF02253731 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253731 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wirtshafter David Department of Psychology and Committee on Neuroscience, University of Illinois at Chicago, Box 4348, 60680, Chicago, Il, USA aut NATIONALLICENCE 700 1- Krebs Joseph Department of Psychology and Committee on Neuroscience, University of Illinois at Chicago, Box 4348, 60680, Chicago, Il, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/1(1990-05-01), 137-141 0033-3158 101:1<137 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer