caa a22 4500 465737846 CHVBK 20180323111759.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF02253717 doi (NATIONALLICENCE)springer-10.1007/BF02253717 Behavioral effects of MK-801 in the rat [Elektronische Daten] [D. Wozniak, J. Olney, L. Kettinger III, M. Price, J. Miller] Several experiments were conducted to study the effects of the noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801, on learning and memory in the rat. Rats displayed impaired performance on several sensorimotor tests and appeared grossly intoxicated when treated IP with 0.2 mg/kg MK-801, but not when treated with lower doses (0.05 or 0.1 mg/kg). Postacquisition performance on two spatial learning tasks involving working memory protocols (reinforced alternation and radial arm maze) was impaired by MK-801 at intoxicating doses (≥0.2 mg/kg) but not at lower doses (0.05 or 0.1 mg/kg). Using a position habit reversal task, we found that rats could learn to reverse a position habit while under the influence of a nonintoxicating dose of MK-801 (0.1 mg/kg), but when tested on the following day performed as if they did not recall what they had learned. Thus, acute administration of a nonintoxicating dose of MK-801 disrupts the retention of new information learned under the influence of the drug but does not interfere with the performance of tasks that are well learned before the drug is administered. Whether the performance deficits on the spatial learning tasks observed only following intoxicating doses of MK-801 reflect an effect on memory is not clear. Springer-Verlag, 1990 MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] nationallicence N-methyl- d -aspartate receptor antagonists nationallicence Learning and memory nationallicence Sensorimotor function nationallicence Wozniak D. Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut Olney J. Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut Kettinger III L. Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut Price M. Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut Miller J. Department of Division of Biostatistics, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut Psychopharmacology Springer-Verlag 101/1(1990-05-01), 47-56 0033-3158 101:1<47 1990 101 213 https://doi.org/10.1007/BF02253717 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253717 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wozniak D. Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Olney J. Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Kettinger III L. Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Price M. Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Miller J. Department of Division of Biostatistics, Washington University School of Medicine, 4940 Audubon Avenue, 63110, St. Louis, MO, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/1(1990-05-01), 47-56 0033-3158 101:1<47 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer