caa a22 4500 465737943 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244059 doi (NATIONALLICENCE)springer-10.1007/BF02244059 Initial sensitivity, acute tolerance and alcohol consumption in four inbred strains of rats [Elektronische Daten] [Jatinder Khanna, Harold Kalant, Anita Chau, Harish Sharma] Initial sensitivity and acute tolerance to ethanol were determined in a jumping test in separate groups of spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats, and of Dahl salt-sensitive (SS) and salt-resistant (SR) rats. One week later, voluntary consumption of ethanol was studied in all groups. SH rats were found to be more sensitive than WKY, but there was no difference in acute tolerance development between these two strains. SH rats, however, drank significantly more alcohol than the WKY in both the two-bottle choice paradigm and the limited access model. Similarly, SS rats drank significantly more alcohol than the SR rats, although SS rats were found to be more sensitive to ethanol than SR. There was again no difference in acute tolerance development between these two strains. These observations suggest that difference in alcohol consumption in these strains cannot be accounted for by significant differences in acute tolerance or in initial sensitivity to ethanol. Springer-Verlag, 1990 Sensitivity nationallicence Acute tolerance nationallicence Drinking nationallicence Strains nationallicence Rat nationallicence Khanna Jatinder Department of Pharmacology, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut Kalant Harold Department of Pharmacology, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut Chau Anita Department of Pharmacology, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut Sharma Harish Department of Pharmacology, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 390-395 0033-3158 101:3<390 1990 101 213 https://doi.org/10.1007/BF02244059 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244059 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khanna Jatinder Department of Pharmacology, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Kalant Harold Department of Pharmacology, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Chau Anita Department of Pharmacology, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Sharma Harish Department of Pharmacology, University of Toronto, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 390-395 0033-3158 101:3<390 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer