caa a22 4500 465737951 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244053 doi (NATIONALLICENCE)springer-10.1007/BF02244053 Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone [Elektronische Daten] [A. Fernández-Guasti, C. López-Rubalcava] The systemic injection of diazepam (0.5 and 1.0 mg/kg), indorenate (5 and 10 mg/kg) and ipsapirone (2.5 and 5.0 mg/kg) reduced anxiety as tested in an exploratory avoidance model in mice. The injection of pindolol (2.0 mg/kg), alprenolol (5.0 mg/kg) or methiotepin (0.25 mg/kg) effectively prevented the anxiolytic action of indorenate and ipsapirone. The combined treatment of the antagonists with indorenate or ipsapirone did not reduce the motor activity, therefore suggesting that the inhibition of exploratory behaviour, after such combinations, was not mediated through a general motor impairment. Neither diazepam nor indorenate alone modified the motor activity; ipsapirone (5 and 2.5 mg/kg), however, reduced ambulation. This reduction was also prevented by administering pindolol, alprenolol or methiotepin. These observations suggest that the anxiolytic actions of indorenate and ipsapirone are mediated via stimulation of the 5-HT1A like receptor subtype. Springer-Verlag, 1990 Ipsapirone nationallicence Indorenate nationallicence 5-HT1A receptors nationallicence Pindolol nationallicence Alprenolol nationallicence Methiotepin nationallicence Anxiety nationallicence Exploration in mice nationallicence Fernández-Guasti A. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., México aut López-Rubalcava C. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., México aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 354-358 0033-3158 101:3<354 1990 101 213 https://doi.org/10.1007/BF02244053 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244053 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernández-Guasti A. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., México aut NATIONALLICENCE 700 1- López-Rubalcava C. Sección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV and División de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatría, México D.F., México aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 354-358 0033-3158 101:3<354 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer