caa a22 4500 46573796X CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244047 doi (NATIONALLICENCE)springer-10.1007/BF02244047 Chronic corticosterone administration modulates nicotine sensitivity and brain nicotinic receptor binding in C3H mice [Elektronische Daten] [J. Pauly, E. Grün, A. Collins] Glucocorticoid regulation of nicotine sensitivity was investigated in adrenalectomized (ADX) and sham-operated C3H mice administered chronic corticosterone (CCS) replacement therapy. Hormone pellets (60% CCS or pure cholesterol) were implanted at the time of surgery and animals were tested for nicotine sensitivity in a battery of behavioral and physiological tests. ADX-induced increases in nicotine sensitivity were reversed by chronic CCS replacement. Sham-operated animals that received CCS supplementation were subsensitive to the effects of nicotine. In both ADX and sham-operated animals, chronic CCS administration induced a decrease in the number of CNS nicotinic cholinergic receptors labeled by alpha-[125I]-bungarotoxin. Binding was decreased by 30-60% depending on brain region; no changes in affinity (K d ) were detected. The number of brain nicotinic sites labeled by [3H]-nicotine was unaltered following 1 week of chronic CCS administration. These data support the hypothesis that glucocorticoids modulate nicotine sensitivity in the C3H mouse. In animals chronically treated with CCS, nicotine tolerance may be due to CCS-induced changes in nicotinic cholinergic receptor binding or the presence of high CCS titers at the time of testing. Springer-Verlag, 1990 Nicotine nationallicence Bungarotoxin nationallicence Cholinergic receptor binding nationallicence Corticosterone nationallicence Glucocorticoids nationallicence Adrenalectomy nationallicence Pauly J. Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut Grün E. Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut Collins A. Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 310-316 0033-3158 101:3<310 1990 101 213 https://doi.org/10.1007/BF02244047 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244047 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pauly J. Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut NATIONALLICENCE 700 1- Grün E. Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut NATIONALLICENCE 700 1- Collins A. Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 310-316 0033-3158 101:3<310 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer