caa a22 4500 465737978 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244056 doi (NATIONALLICENCE)springer-10.1007/BF02244056 Effect of imipramine in the "learned helplessness” model of depression in rats is not mimicked by combinations of specific reuptake inhibitors and scopolamine [Elektronische Daten] [Marianne Geoffroy, Jørgen Scheel-Krüger, Anne Christensen] Administration of imipramine, which blocks noradrenergic, serotonergic and cholinergic reuptake, to rats for 4 days counteracts the shuttlebox escape failures otherwise seen in rats which have been exposed to inescapable shock (the "learned helplessness” model of depression). The effects of the more selective reuptake inhibitors talsupram (noradrenergic), citalopram (serotonergic) and the anticholinergic compound scopolamine were assessed alone and in combination after acute or 4 days' administration on escape behavior. Their possible synergistic effects when combined with imipramine were also assessed. Talsupram and citalopram were ineffective, whereas scopolamine counteracted the escape failures. Combinations of talsupram, citalopram and a subeffective dose of scopolamine were ineffective. A synergistic effect was only seen when scopolamine was combined with a suboptimal dose of imipramine. Thus, the effect of imipramine on "learned helplessness” might rely partly on its anticholinergic component. However, as an acute high dose of imipramine (25 mg/kg) was ineffective [unlike the acute administration of scopolamine (0.12 mg/kg)], this drug retains a pharmacological effect which is not mimicked by scopolamine alone or by combining the specific reuptake inhibitors with scopolamine. Springer-Verlag, 1990 Shock stress nationallicence Learned helplessness nationallicence Imipramine nationallicence Reuptake inhibitors nationallicence Rat nationallicence Geoffroy Marianne Psychopharmacological Research Laboratory, St. Hans Hospital, DK-4000, Roskilde, Denmark aut Scheel-Krüger Jørgen Psychopharmacological Research Laboratory, St. Hans Hospital, DK-4000, Roskilde, Denmark aut Christensen Anne Psychopharmacological Research Laboratory, St. Hans Hospital, DK-4000, Roskilde, Denmark aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 371-375 0033-3158 101:3<371 1990 101 213 https://doi.org/10.1007/BF02244056 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244056 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Geoffroy Marianne Psychopharmacological Research Laboratory, St. Hans Hospital, DK-4000, Roskilde, Denmark aut NATIONALLICENCE 700 1- Scheel-Krüger Jørgen Psychopharmacological Research Laboratory, St. Hans Hospital, DK-4000, Roskilde, Denmark aut NATIONALLICENCE 700 1- Christensen Anne Psychopharmacological Research Laboratory, St. Hans Hospital, DK-4000, Roskilde, Denmark aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 371-375 0033-3158 101:3<371 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer