caa a22 4500 465738001 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244050 doi (NATIONALLICENCE)springer-10.1007/BF02244050 Brain μ and δ opioid receptors mediate different locomotor hyperactivity responses of the C57BL/6J mouse [Elektronische Daten] [G. Andrew Mickley, Maureen Mulvihill, Mark Postler] Morphine induces a dose-dependent stereotypic locomotor hyperactivity in the C57BL/6J mouse. Although morphine is the prototypical opioid μ receptor agonist, it also binds at δ sites. This has led to speculation as to which set(s) of receptor subtypes mediate opiate-induced locomotor hyperactivity. Here we use selective μ and δ receptor agonists as well as a sophisticated activity measuring apparatus to investigate the neuropharmacology of opioid-induced locomotion in the mouse. Male C57BL/6J mice were implanted with chronic bilateral cannula aimed at the lateral ventricles. Following recovery from surgery, mice received a series of bilateral 1 µl intraventricular (i.vent.) injections of [D-Ala2-MePhe4-Glyol5] enkephalin (DAGO) (0.1, 1.0, 2.0 µg), [D-Pen2, D-Pen5] enkephalin (DPDPE) (2.5, 5.0, 10.0, 30.0 µg) (compounds with respective μ and δ opioid receptor selectivity), morphine sulfate (10.0, 20.0, 60.0 µg), or saline. Injections were separated by at least 3 days and were presented in a randomized order. We measured several locomotor parameters following each injection. DAGO, DPDPE and morphine each produced horizontal locomotor hyperactivity and lengthened the average distance per move. While morphine and DAGO significantly reduced vertical activity (rearing) and produced thigmotaxis (wall-hugging), DPDPE-injected mice were similar to controls on these locomotor parameters. These data reveal that mouse locomotor hyperactivity can be observed following injections of either morphine or more-selective opioid μ or δ receptor agonists. However, within the drug/dose regimens used here, we noticed qualitative differences in the locomotor topography produced by the selective μ and δ receptor agonists. Springer-Verlag, 1990 Opiates nationallicence Locomotion nationallicence Mice nationallicence Opioid receptors nationallicence Thigmotaxis nationallicence Andrew Mickley G. Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, 20814-5145, Bethesda, MD, USA aut Mulvihill Maureen Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, 20814-5145, Bethesda, MD, USA aut Postler Mark Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, 20814-5145, Bethesda, MD, USA aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 332-337 0033-3158 101:3<332 1990 101 213 https://doi.org/10.1007/BF02244050 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244050 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andrew Mickley G. Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, 20814-5145, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Mulvihill Maureen Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, 20814-5145, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Postler Mark Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, 20814-5145, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 332-337 0033-3158 101:3<332 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer