caa a22 4500 465738028 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244062 doi (NATIONALLICENCE)springer-10.1007/BF02244062 8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition [Elektronische Daten] [J. Shepherd, R. Rodgers] The behavioural specificity of the hyperphagic effects of 8-OH-DPAT is a controversial issue. The present study addressed this question through the introduction of behavioural competition. Feeding behaviour in male mice was assessed under both basal (free-feeding) and social conflict conditions. Since, in the latter condition, defence and escape are prepotent responses, elicitation of feeding would be indicative of a specific treatment effect on mechanisms controlling food intake. Results showed that 8-OH-DPAT enhanced basal feeding duration (at doses of 0.05-0.50 mg/kg) and also elicited feeding in intruder mice during encounters with aggressive resident conspecifics (at doses of 0.10-0.50 mg/kg). As the 5-HT3 antagonist GR 38032F (1.0-2.0 mg/kg) enhanced feeding only under basal conditions, the effect of 8-OH-DPAT cannot readily be attributed to anxiety reduction. Finally, diazepam (1.0-2.0 mg/kg) produced a similar profile to that of 8-OH-DPAT, suggesting that the hyperphagic effects of the 5-HT1A agonist are not pharmacologically specific. Springer-Verlag, 1990 Feeding nationallicence Behavioural specificity nationallicence 8-OH-DPAT nationallicence GR38032F nationallicence Diazepam nationallicence Mice nationallicence Shepherd J. Pharmacoethology Laboratory, Department of Psychology, University of Leeds, LS2 9JT, Leeds, UK aut Rodgers R. Pharmacoethology Laboratory, Department of Psychology, University of Leeds, LS2 9JT, Leeds, UK aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 408-413 0033-3158 101:3<408 1990 101 213 https://doi.org/10.1007/BF02244062 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244062 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shepherd J. Pharmacoethology Laboratory, Department of Psychology, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Rodgers R. Pharmacoethology Laboratory, Department of Psychology, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 408-413 0033-3158 101:3<408 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer