caa a22 4500 465738052 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244061 doi (NATIONALLICENCE)springer-10.1007/BF02244061 Reversal of helpless behavior by serotonin uptake blockers in rats [Elektronische Daten] [Patrick Martin, Philippe Soubrié, Alain Puech] Serotonergic systems are thought to be involved in the mechanisms of action of antidepressants in humans. There is little evidence, however, to suggest that serotonin uptake blockers are efficacious in animal models of depression. To further explore the antidepressant activity of these drugs, four compounds from this class (citalopram, fluvoxamine, indalpine or zimelidine) were tested in rats subjected to helplessness training. Rats were first exposed to inescapable shocks and 48 h later, shuttle-box training was initiated to evaluate escape learning. Twice-daily IP injections of citalopram (1 mg/kg), fluvoxamine (4 mg/kg), indalpine (1 and 2 mg/kg) and zimelidine (1 and 2 mg/kg) reduced escape deficits in a manner similar to that produced by the tricyclic antidepressants desipramine and clomipramine. Reversal of escape deficit by serotonin uptake blockers was observed only when the drugs were administered after the shuttle-box sessions. At higher doses, the four serotonin uptake blockers were without effect. These data suggest that serotonin uptake blockers exert antidepressant-like effects in animals but only when they produce a moderate stimulation of serotonin neurotransmission. Springer-Verlag, 1990 Serotonin uptake blockers nationallicence Learned helplessness nationallicence Rats nationallicence Depression nationallicence Martin Patrick Département de Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l'Hôpital, F-75634, Paris Cedex 13, France aut Soubrié Philippe Département de Neurobiologie, Sanofi Recherche, Rue du Pr. J. Blayac, F-34082, Montpellier Cedex, France aut Puech Alain Département de Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l'Hôpital, F-75634, Paris Cedex 13, France aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 403-407 0033-3158 101:3<403 1990 101 213 https://doi.org/10.1007/BF02244061 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244061 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martin Patrick Département de Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l'Hôpital, F-75634, Paris Cedex 13, France aut NATIONALLICENCE 700 1- Soubrié Philippe Département de Neurobiologie, Sanofi Recherche, Rue du Pr. J. Blayac, F-34082, Montpellier Cedex, France aut NATIONALLICENCE 700 1- Puech Alain Département de Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l'Hôpital, F-75634, Paris Cedex 13, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 403-407 0033-3158 101:3<403 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer