caa a22 4500 465738087 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244063 doi (NATIONALLICENCE)springer-10.1007/BF02244063 Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens [Elektronische Daten] [N. Swerdlow, D. Braff, V. Masten, M. Geyer] Previous studies have demonstrated that several dopamine agonists disrupt sensorimotor gating as measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. Schizophrenic patients also exhibit deficits in PPI when the prepulse preceeds the startle stimulus by less than 500 ms. In experiment 1, dopamine (0-40 µg) infused directly into the nucleus accumbens in rats caused a dose-dependent decrease in PPI at prepulse intervals shorter than 500 ms. In experiment 2, this effect of accumbens dopamine infusions on sensorimotor gating was found to vary with changes in prepulse intensity. These findings strongly suggest that increased mesolimbic dopamine activity is one substrate of the sensorimotor gating deficits in rats that are caused by treatment with dopamine agonists; similar substrates might mediate deficits in PPI exhibited by schizophrenic patients. Springer-Verlag, 1990 Acoustic startle response nationallicence Dopamine nationallicence Nucleus accumbens nationallicence Prepulse inhibition nationallicence Schizophrenia nationallicence Sensorimotor gating nationallicence Swerdlow N. Department of Psychiatry, T-004, University of California at San Diego, 92093, La Jolla, CA, USA aut Braff D. Department of Psychiatry, T-004, University of California at San Diego, 92093, La Jolla, CA, USA aut Masten V. Department of Psychiatry, T-004, University of California at San Diego, 92093, La Jolla, CA, USA aut Geyer M. Department of Psychiatry, T-004, University of California at San Diego, 92093, La Jolla, CA, USA aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 414-420 0033-3158 101:3<414 1990 101 213 https://doi.org/10.1007/BF02244063 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244063 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Swerdlow N. Department of Psychiatry, T-004, University of California at San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Braff D. Department of Psychiatry, T-004, University of California at San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Masten V. Department of Psychiatry, T-004, University of California at San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Geyer M. Department of Psychiatry, T-004, University of California at San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 414-420 0033-3158 101:3<414 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer