caa a22 4500 465738095 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244051 doi (NATIONALLICENCE)springer-10.1007/BF02244051 Changes in locomotion and dopamine neurotransmission following amphetamine, haloperidol, and exposure to novel environmental stimuli [Elektronische Daten] [M. Bardo, S. Bowling, R. Pierce] Locomotor behavior and dopamine (DA) neurotransmission were assessed in rats exposed to either a novel or familiar stimulus environment while under the influence of amphetamine, haloperidol or saline. The behavioral results indicated that, as expected, amphetamine increased horizontal locomotor activity in a dose-dependent manner. Exposure to novelty also increased horizontal activity, and this behavioral effect was disrupted by both amphetamine and haloperidol. Regardless of whether the animals were exposed to the novel or familiar stimulus environment, amphetamine increased DA synthesis in the nigrostriatal system, but not in the mesolimbic system, whereas haloperidol increased DA synthesis in both the nigrostriatal and mesolimbic systems. Amphetamine also decreased DA metabolism and haloperidol increased DA metabolism in both the nigrostriatal and mesolimbic systems. In contrast, exposure to novelty alone was without effect on DA synthesis or metabolism in any region examined, suggesting that novelty-induced hyperactivity and amphetamine-induced hyperactivity involve different neurochemical mechanisms. However, exposure to novelty while under the influence of haloperidol produced a significant increase in DA metabolism in both the nigrostriatal and mesolimbic systems. These latter results suggest that exposure to novelty may produce a measurable activation of DA systems when the autoreceptors involved in the negative feedback loop are blocked. Springer-Verlag, 1990 Amphetamine nationallicence Haloperidol nationallicence Novelty nationallicence Locomotor activity nationallicence Dopamine nationallicence Nigrostriatal system nationallicence Mesolimbic system nationallicence Bardo M. Department of Psychology, University of Kentucky, 40506, Lexington, KY, USA aut Bowling S. Department of Psychology, University of Kentucky, 40506, Lexington, KY, USA aut Pierce R. Department of Psychology, University of Kentucky, 40506, Lexington, KY, USA aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 338-343 0033-3158 101:3<338 1990 101 213 https://doi.org/10.1007/BF02244051 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244051 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bardo M. Department of Psychology, University of Kentucky, 40506, Lexington, KY, USA aut NATIONALLICENCE 700 1- Bowling S. Department of Psychology, University of Kentucky, 40506, Lexington, KY, USA aut NATIONALLICENCE 700 1- Pierce R. Department of Psychology, University of Kentucky, 40506, Lexington, KY, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 338-343 0033-3158 101:3<338 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer