caa a22 4500 465738117 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF02244049 doi (NATIONALLICENCE)springer-10.1007/BF02244049 Relationships between clinical effects and monoamine metabolites and amino acids in sulpiride-treated schizophrenic patients [Elektronische Daten] [Gunnel Alfredsson, Frits-Axel Wiesel] Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (400, 800 or 1200 mg) according to a double dummy blind randomized administration schedule. The psychopathology of the patients was rated by the Comprehensive Psychopathological Rating Scale (CPRS) and the Nurse's Observation Scale for Inpatient Evaluation (NOSIE). The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA), 4-hydroxy-3-methoxy-phenylglycol (HMPG) and the amino acids tyrosine, tryptophan, glutamate and glutamine were measured in serum before and once a week during sulpiride treatment. There were no significant correlations between the CPRS or the NOSIE morbidity scores and the biochemical measures before drug treatment. HVA levels were not correlated to rating scores during treatment, but after 6 weeks HVA had decreased significantly in the patients with a good response but not in the patients with a poor response. A negative relationship between 5-HIAA levels and depressive and negative symptoms was found. Nonresponders according to the subscale for depression had low 5-HIAA levels throughout the treatment. An increase of tryptophan was correlated to improvement in the early part of treatment. High levels of glutamate or glutamine were found in non-responders before treatment. During treatment an increase of the glutamate level was correlated to improvement. Low levels of glutamine were related to improvement according to global and NOSIE (total) rating scores. Peripheral biochemical measures may be a valuable tool in the study of pathophysiological mechanisms and treatment effects in patients with schizophrenia. Springer-Verlag, 1990 Sulpiride nationallicence Schizophrenia nationallicence Serum nationallicence Monoamine metabolites nationallicence Amino acids nationallicence Alfredsson Gunnel Department of Psychiatry, Uppsala University, Ulleråker, S-750 17, Uppsala, Sweden aut Wiesel Frits-Axel Department of Psychiatry, Uppsala University, Ulleråker, S-750 17, Uppsala, Sweden aut Psychopharmacology Springer-Verlag 101/3(1990-07-01), 324-331 0033-3158 101:3<324 1990 101 213 https://doi.org/10.1007/BF02244049 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244049 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alfredsson Gunnel Department of Psychiatry, Uppsala University, Ulleråker, S-750 17, Uppsala, Sweden aut NATIONALLICENCE 700 1- Wiesel Frits-Axel Department of Psychiatry, Uppsala University, Ulleråker, S-750 17, Uppsala, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/3(1990-07-01), 324-331 0033-3158 101:3<324 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer