caa a22 4500 465738168 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02244239 doi (NATIONALLICENCE)springer-10.1007/BF02244239 Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans [Elektronische Daten] [A. Sharpley, R. Solomon, A. Fernando, J. da Roza Davis, P. Cowen] The effects of the selective 5-HT2 receptor antagonists, ritanserin (1, 5 and 10 mg) and ICI 169,369 (50 and 100 mg), were studied on the sleep EEG of healthy volunteers using home-based Medilog 9000 cassette monitoring. Ritanserin (5 and 10 mg) produced a significant increase in slow wave sleep (SWS) while ICI 169,369 also increased SWS but only at a dose of 100 mg. These findings are consistent with the proposal that selective 5-HT2 receptor blockade increases SWS in humans; however, the data cannot exclude involvement of the closely related 5-HT1c receptor in this effect. Springer-Verlag, 1990 Slow wave sleep nationallicence 5-HT2/1c receptor nationallicence Ritanserin nationallicence ICI 169,369 nationallicence Home sleep recordings nationallicence Sharpley A. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Solomon R. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Fernando A. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut da Roza Davis J. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut Psychopharmacology Springer-Verlag 101/4(1990-08-01), 568-569 0033-3158 101:4<568 1990 101 213 https://doi.org/10.1007/BF02244239 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244239 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sharpley A. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- Solomon R. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- Fernando A. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- da Roza Davis J. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 700 1- Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Oxford, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/4(1990-08-01), 568-569 0033-3158 101:4<568 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer