caa a22 4500 465738176 CHVBK 20180323111800.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02244224 doi (NATIONALLICENCE)springer-10.1007/BF02244224 Conditioning of morphine-induced taste aversion and analgesia [Elektronische Daten] [James Miller, Kimberly Kelly, Janet Neisewander, D. McCoy, Michael Bardo] The process of selective associations is evident in the aversive conditioning literature, where it has been shown that external cues are readily associated with peripheral pain, whereas taste cues are more easily associated with effects of drug administration. Within this framework, it is of interest that the failures to obtain a conditioned analgesic response to a morphine-associated CS have used external cues as conditioned stimuli. In Experiment 1, subjects re-exposed to a morphine-associated CS not only expressed the anticipated taste aversion, but also exhibited a decrease in pain sensitivity that was evident 15 or 30 min following CS re-exposure. Experiment 2 suggested that the conditioned analgesic response was opioid mediated, as pre-test administration of naloxone blocked expression of the analgesic CR. In Experiment 3, an increase in opiate receptor sensitivity produced by chronic naltrexone treatment did not affect the strength of the taste aversion, but resulted in an increase in the magnitude of the conditioned analgesic response. Collectively, these data suggest a neuropharmacological dissociation in systems mediating the two responses. Springer-Verlag, 1990 Morphine nationallicence Conditioned taste aversion nationallicence Opioid-mediated analgesia nationallicence Miller James Department of Psychology, University of Kentucky, Lexington, KY, USA aut Kelly Kimberly Department of Psychology, University of Kentucky, Lexington, KY, USA aut Neisewander Janet Department of Psychology, University of Kentucky, Lexington, KY, USA aut McCoy D. Department of Psychology, University of Kentucky, Lexington, KY, USA aut Bardo Michael Department of Psychology, University of Kentucky, Lexington, KY, USA aut Psychopharmacology Springer-Verlag 101/4(1990-08-01), 472-480 0033-3158 101:4<472 1990 101 213 https://doi.org/10.1007/BF02244224 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244224 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miller James Department of Psychology, University of Kentucky, Lexington, KY, USA aut NATIONALLICENCE 700 1- Kelly Kimberly Department of Psychology, University of Kentucky, Lexington, KY, USA aut NATIONALLICENCE 700 1- Neisewander Janet Department of Psychology, University of Kentucky, Lexington, KY, USA aut NATIONALLICENCE 700 1- McCoy D. Department of Psychology, University of Kentucky, Lexington, KY, USA aut NATIONALLICENCE 700 1- Bardo Michael Department of Psychology, University of Kentucky, Lexington, KY, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/4(1990-08-01), 472-480 0033-3158 101:4<472 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer