caa a22 4500 465738192 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02244238 doi (NATIONALLICENCE)springer-10.1007/BF02244238 A matching law analysis of the effects of dopamine receptor antagonists [Elektronische Daten] [Paul Willner, David Sampson, Gavin Phillips, Richard Muscat] Herrnstein's matching equation was used to analyze drug effects on performance in random interval reinforcement schedules. Pimozide caused effects compatible with both motor and motivational impairments, in a 5-component multiple schedule, a 3-schedule 3-day cycle (ALT-3), and a 2-schedule 2-day cycle (ALT-2). However, at low doses, both sulpiride and SCH-23390, tested in the ALT-3 and ALT-2 procedures, caused effects compatible with selective motivational impairments. In experiments using the non-multiple schedules, motivational effects increased during the course of the experimental session, under all three drugs. The interpretation of "motor” and "motivational” deficits in the ALT-2 procedure was validated by experiments in which the response-force and deprivation level were systematically varied. The results support the view that dopamine may be involved in the maintenance of rewarded behaviour, but do not differentially implicate the D1 or the D2 receptor subtype. Springer-Verlag, 1990 Herrnstein's equation nationallicence Dopamine antagonists nationallicence Reinforcement nationallicence Motor capacity nationallicence Rat nationallicence Willner Paul Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Sampson David Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Phillips Gavin Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Muscat Richard Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Psychopharmacology Springer-Verlag 101/4(1990-08-01), 560-567 0033-3158 101:4<560 1990 101 213 https://doi.org/10.1007/BF02244238 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244238 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Willner Paul Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Sampson David Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Phillips Gavin Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Muscat Richard Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/4(1990-08-01), 560-567 0033-3158 101:4<560 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer