caa a22 4500 465738214 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02244233 doi (NATIONALLICENCE)springer-10.1007/BF02244233 Aversion instead of preference learning indicated by nicotine place conditioning in rats [Elektronische Daten] [Douglas Jorenby, Rhea Steinpreis, Jack Sherman, Timothy Baker] Although nicotine is a drug of abuse for millions of smokers, it has been difficult to demonstrate clearly the motivational properties of nicotine with rats using the conditioned place preference (CPP) paradigm. The first experiment attempted to replicate CPPs reported by other researchers using nicotine doses of 0.4, 0.8, and 1.2 mg/kg. There was a trend for all three doses to produce aversions, but it was significant only for the 0.8 mg/kg dose. Exposures to the CS alone extinguished aversions, but a "priming” dose (0.2 mg/kg) of nicotine given after extinction produced aversions only in animals exposed to 1.2 mg/kg. Experiment 2 tested whether preexposure to morphine or nicotine would sensitize animals to nicotine's reinforcing effects. In this experiment, rats were exposed to either six nicotine (0.6 mg/kg) or morphine (1.0 mg/kg) dosings prior to preference conditioning. Neither preferences nor aversions were observed in any group following subsequent conditioning with 0.6 mg/kg nicotine. The results suggest that previous observations of preference effects may have been due to specific procedural factors or may have depended on negative reinforcement due to stress reduction. Springer-Verlag, 1990 Place conditioning nationallicence Nicotine nationallicence Morphine nationallicence Priming nationallicence Rats nationallicence Jorenby Douglas Department of Psychology, University of Wisconsin — Madison, 1202 West Johnson Street, 53706, Madison, WI, USA aut Steinpreis Rhea Department of Psychology, University of Wisconsin — Madison, 1202 West Johnson Street, 53706, Madison, WI, USA aut Sherman Jack Department of Psychology, University of Wisconsin — Madison, 1202 West Johnson Street, 53706, Madison, WI, USA aut Baker Timothy Department of Psychology, University of Wisconsin — Madison, 1202 West Johnson Street, 53706, Madison, WI, USA aut Psychopharmacology Springer-Verlag 101/4(1990-08-01), 533-538 0033-3158 101:4<533 1990 101 213 https://doi.org/10.1007/BF02244233 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244233 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jorenby Douglas Department of Psychology, University of Wisconsin — Madison, 1202 West Johnson Street, 53706, Madison, WI, USA aut NATIONALLICENCE 700 1- Steinpreis Rhea Department of Psychology, University of Wisconsin — Madison, 1202 West Johnson Street, 53706, Madison, WI, USA aut NATIONALLICENCE 700 1- Sherman Jack Department of Psychology, University of Wisconsin — Madison, 1202 West Johnson Street, 53706, Madison, WI, USA aut NATIONALLICENCE 700 1- Baker Timothy Department of Psychology, University of Wisconsin — Madison, 1202 West Johnson Street, 53706, Madison, WI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/4(1990-08-01), 533-538 0033-3158 101:4<533 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer