caa a22 4500 465738273 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02244230 doi (NATIONALLICENCE)springer-10.1007/BF02244230 Diazepam changes risk assessment in an anxiety/defense test battery [Elektronische Daten] [D. Blanchard, Robert Blanchard, Paul Tom, R. Rodgers] An anxiety/defense test battery was designed to assess defensive reactions of laboratory rats to situations associated with nonpainful threat (exposure to a cat). The battery measured three defense patterns, movement inhibition, risk assessment behaviors, and inhibition of nondefensive behaviors, in two tasks. Diazepam (4.0 mg/kg) altered four of five risk assessment measures, but failed to show an anxiolytic effect on movement inhibition, and had minimal and inconsistent effects on inhibition of nondefensive behaviors. The risk assessment changes with diazepam were all consistent with an anxiolytic action of diazepam. These results provide a partial contrast to the general lack of anxiolytic action of diazepam in a fear/defense test battery designed to measure reactions to a discrete, present, threat stimulus, and suggest a greater diazepam effect on risk assessment than on other aspects of defensive responding. Sex differences indicating higher defensiveness for female than male rats were obtained on many of these measures. Springer-Verlag, 1990 Diazepam nationallicence Anxiety nationallicence Defense nationallicence Sex differences nationallicence Rat nationallicence Blanchard D. Bekesy Laboratory of Neurobiology, 1993 East-West Road, 96822, Honolulu, HI, USA aut Blanchard Robert Bekesy Laboratory of Neurobiology, 1993 East-West Road, 96822, Honolulu, HI, USA aut Tom Paul Department of Psychology University of Hawaii, Hawaii, USA aut Rodgers R. Department of Psychology, University of Leeds, Leeds, UK aut Psychopharmacology Springer-Verlag 101/4(1990-08-01), 511-518 0033-3158 101:4<511 1990 101 213 https://doi.org/10.1007/BF02244230 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244230 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blanchard D. Bekesy Laboratory of Neurobiology, 1993 East-West Road, 96822, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Blanchard Robert Bekesy Laboratory of Neurobiology, 1993 East-West Road, 96822, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Tom Paul Department of Psychology University of Hawaii, Hawaii, USA aut NATIONALLICENCE 700 1- Rodgers R. Department of Psychology, University of Leeds, Leeds, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/4(1990-08-01), 511-518 0033-3158 101:4<511 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer