caa a22 4500 465738281 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02244236 doi (NATIONALLICENCE)springer-10.1007/BF02244236 Chlordiazepoxide reduces discriminability but not rate of forgetting in delayed conditional discrimination [Elektronische Daten] [S. Tan, R. Kirk, W. Abraham, N. McNaughton] Benzodiazepine and anticholinergic drugs interfere with septo-hippocampal function in similar but not identical ways. They also share a number of common behavioural effects and, in particular, both classes of drug interfere with spatial memory in the Morris Water Maze — a test which is very sensitive to hippocampal dysfunction. We have previously shown that the anticholinergic drug scopolamine impairs discriminability, but not rate of forgetting, in delayed conditional discrimination. In the present study forgetting was quantified by fitting a negative exponential function to estimates of discriminability derived from a signal detection analysis of data from an auditory delayed conditional discrimination task. Chlordiazepoxide produced a highly significant decrease in discriminability which was monotonically related to the logarithm of dose in the range 0.67-18.0 mg/kg IP. The rate of forgetting was not increased. These data confirm the pharmacological independence of changes in discriminability and rate of forgetting; demonstrate that in this task chlordiazepoxide has similar effects to scopolamine; and suggest that the effects of chlordiazepoxide in other working memory tasks could be more a result of changed stimulus processing than impairment of memorial processes. Springer-Verlag, 1990 Chlordiazepoxide nationallicence Benzodiazepine nationallicence Memory nationallicence Discriminability nationallicence Tan S. Department of Psychology and Centre for Neuroscience, University of Otago, P.O. Box 56, Dunedin, New Zealand aut Kirk R. Department of Psychology and Centre for Neuroscience, University of Otago, P.O. Box 56, Dunedin, New Zealand aut Abraham W. Department of Psychology and Centre for Neuroscience, University of Otago, P.O. Box 56, Dunedin, New Zealand aut McNaughton N. Department of Psychology and Centre for Neuroscience, University of Otago, P.O. Box 56, Dunedin, New Zealand aut Psychopharmacology Springer-Verlag 101/4(1990-08-01), 550-554 0033-3158 101:4<550 1990 101 213 https://doi.org/10.1007/BF02244236 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244236 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tan S. Department of Psychology and Centre for Neuroscience, University of Otago, P.O. Box 56, Dunedin, New Zealand aut NATIONALLICENCE 700 1- Kirk R. Department of Psychology and Centre for Neuroscience, University of Otago, P.O. Box 56, Dunedin, New Zealand aut NATIONALLICENCE 700 1- Abraham W. Department of Psychology and Centre for Neuroscience, University of Otago, P.O. Box 56, Dunedin, New Zealand aut NATIONALLICENCE 700 1- McNaughton N. Department of Psychology and Centre for Neuroscience, University of Otago, P.O. Box 56, Dunedin, New Zealand aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/4(1990-08-01), 550-554 0033-3158 101:4<550 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer