caa a22 4500 46573832X CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF02244231 doi (NATIONALLICENCE)springer-10.1007/BF02244231 Sensitization versus tolerance to the dopamine turnover-elevating effects of haloperidol: the effect of regular/intermittent dosing [Elektronische Daten] [John Csernansky, Elisabeth Bellows, Deborah Barnes, Leon Lombrozo] Recent clinical research suggests that particular patterns of changes in presynaptic dopamine (DA) turnover accompany the therapeutic response to neuroleptics. We sought to determine whether daily versus weekly dosing of haloperidol for 3 weeks produced distinct effects on DA, dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) concentrations in multiple brain areas. Daily dosing favored the development of tolerance to the DA-turnover elevating effects of haloperidol in the striatum and nucleus accumbens. Weekly dosing favored the development of sensitization in the striatum, posterior olfactory tubercle, and ventral tegmental area. These results suggest that dosing schedules may determine, at least in part, the effects of chronic neuroleptic administration on presynaptic DA function. Springer-Verlag, 1990 Dopamine turnover nationallicence Dihydroxyphenylacetic acid nationallicence Homovanillic acid nationallicence Sensitization nationallicence Neuroleptic nationallicence Csernansky John Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 94305, Stanford, CA, USA aut Bellows Elisabeth Department of Veterans Affairs Medical Center (116A8), Laboratory of Clinical Psychopharmacology, 3801 Miranda Avenue, 94304, Palo Alto, CA, USA aut Barnes Deborah Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 94305, Stanford, CA, USA aut Lombrozo Leon Department of Veterans Affairs Medical Center (116A8), Laboratory of Clinical Psychopharmacology, 3801 Miranda Avenue, 94304, Palo Alto, CA, USA aut Psychopharmacology Springer-Verlag 101/4(1990-08-01), 519-524 0033-3158 101:4<519 1990 101 213 https://doi.org/10.1007/BF02244231 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244231 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Csernansky John Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Bellows Elisabeth Department of Veterans Affairs Medical Center (116A8), Laboratory of Clinical Psychopharmacology, 3801 Miranda Avenue, 94304, Palo Alto, CA, USA aut NATIONALLICENCE 700 1- Barnes Deborah Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Lombrozo Leon Department of Veterans Affairs Medical Center (116A8), Laboratory of Clinical Psychopharmacology, 3801 Miranda Avenue, 94304, Palo Alto, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/4(1990-08-01), 519-524 0033-3158 101:4<519 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer