caa a22 4500 465738346 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244126 doi (NATIONALLICENCE)springer-10.1007/BF02244126 Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol [Elektronische Daten] [Michael Durcan, Richard Lister, Markku Linnoila] The centrally active inhibitors of phenylethanolamine-N-methyltransferase (PNMT), LY 78335 and LY 134046, were investigated both alone and in combination with ethanol (2 g/kg) in a holeboard test of directed exploration and locomotor activity. Both PNMT inhibitors showed dose-related reductions in exploratory head-dipping but were without effect on locomotor activity. In combination with ethanol both PNMT inhibitors tended to attenuate the ethanol-induced reductions in exploratory head-dipping but did not effect ethanol's locomotor stimulant properties. LY 134046 showed neither an anxiolytic nor an anxiogenic profile in the plusmaze test of anxiety, nor did it alter the anxiolytic effects of either 1.2 g/kg or 2 g/kg ethanol. LY 134046 did, however, attenuate the ataxic effects of a 2.4 g/kg dose of ethanol. These results may suggest a role for adrenaline synthesis in some, but not all, of the behavioral effects of ethanol. Springer-Verlag, 1990 Phenylethanolamine-N-methyltransferase (PNMT) nationallicence Ethanol nationallicence Locomotion nationallicence Exploration nationallicence Anxiety nationallicence Ataxia nationallicence Durcan Michael Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Building 10 Room 3C102, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Lister Richard Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Building 10 Room 3C102, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Linnoila Markku Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Building 10 Room 3C102, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 196-202 0033-3158 101:2<196 1990 101 213 https://doi.org/10.1007/BF02244126 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244126 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Durcan Michael Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Building 10 Room 3C102, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Lister Richard Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Building 10 Room 3C102, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Linnoila Markku Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Building 10 Room 3C102, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 196-202 0033-3158 101:2<196 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer