caa a22 4500 465738389 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244124 doi (NATIONALLICENCE)springer-10.1007/BF02244124 Effect of serotonergic lesion on "anxious” behaviour measured in the elevated plus-maze test in the rat [Elektronische Daten] [Mike Briley, Philippe Chopin, Chantal Moret] 5,7-Dihydroxytryptamine (250 µg) was administered intracerebroventricularly to rats to lesion central serotonergic neurones. Fourteen days later the rats were tested in the elevated plus-maze "anxiety” model in comparison to sham lesioned animals. Twenty-four hours later, the rats were killed and serotonin levels and [3H]paroxetine binding measured in cortical and hippocampal membranes. The lesion destroyed 81% of the serotonergic innervation in the cortex and 99% in the hippocampus as determined by endogenous serotonin levels. Lesioned rats had an increased ratio of open/total arm entries in the elevated plus-maze, reflecting a decreased level of "anxiety”. These results are compatible with the implication of serotonin in the control of anxiety and suggest that an anxiolytic effect may be induced by lowering the level of serotonergic activation. Springer-Verlag, 1990 5,7-DHT lesion nationallicence Anxiety nationallicence Serotonin levels nationallicence [3H]Paroxetine binding nationallicence Cortex nationallicence Hippocampus nationallicence Briley Mike Centre de Recherche Pierre Fabre, 17, Avenue Jean Moulin, F-81100, Castres, France aut Chopin Philippe Centre de Recherche Pierre Fabre, 17, Avenue Jean Moulin, F-81100, Castres, France aut Moret Chantal Centre de Recherche Pierre Fabre, 17, Avenue Jean Moulin, F-81100, Castres, France aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 187-189 0033-3158 101:2<187 1990 101 213 https://doi.org/10.1007/BF02244124 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244124 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Briley Mike Centre de Recherche Pierre Fabre, 17, Avenue Jean Moulin, F-81100, Castres, France aut NATIONALLICENCE 700 1- Chopin Philippe Centre de Recherche Pierre Fabre, 17, Avenue Jean Moulin, F-81100, Castres, France aut NATIONALLICENCE 700 1- Moret Chantal Centre de Recherche Pierre Fabre, 17, Avenue Jean Moulin, F-81100, Castres, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 187-189 0033-3158 101:2<187 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer