caa a22 4500 465738400 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244137 doi (NATIONALLICENCE)springer-10.1007/BF02244137 Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotonin [Elektronische Daten] [Elliot Loh, David Roberts] The effect of intracerebral injections of 5,7-dihydroxy-tryptamine (5,7-DHT) on cocaine self-administration behavior was assessed. Rats were tested on a progressive ratio (PR) schedule for cocaine reinforcement. The first response on the lever each day produced an IV infusion of cocaine (0.6 mg/injection) after which the requirements of the schedule escalated with each reinforcement until the behavior extinguished. The final ratio completed was defined as the breaking point. Bilateral injections of 5,7-DHT into either the medial forebrain bundle (MFB) or amygdala (AMY) significantly increased the breaking points on the PR schedule compared to vehicle-injected control animals. We interpret these data to indicate that depletion of forebrain serotonin increases the incentive value of cocaine. Springer-Verlag, 1990 Amygdala nationallicence Cocaine nationallicence 5,7-Dihydroxy-tryptamine nationallicence Median forebrain bundle nationallicence Self-administration nationallicence Serotonin nationallicence Loh Elliot Department of Psychology, Carleton University, K1S 5B6, Ottawa, Canada aut Roberts David Department of Psychology, Carleton University, K1S 5B6, Ottawa, Canada aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 262-266 0033-3158 101:2<262 1990 101 213 https://doi.org/10.1007/BF02244137 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244137 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Loh Elliot Department of Psychology, Carleton University, K1S 5B6, Ottawa, Canada aut NATIONALLICENCE 700 1- Roberts David Department of Psychology, Carleton University, K1S 5B6, Ottawa, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 262-266 0033-3158 101:2<262 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer