caa a22 4500 465738427 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244120 doi (NATIONALLICENCE)springer-10.1007/BF02244120 Benzodiazepines and caffeine: effect on daytime sleepiness, performance, and mood [Elektronische Daten] [L. Johnson, C. Spinweber, S. Gomez] In a double-blind parallel group design, 80 young adult males were divided into eight treatment groups. Subjects received 15 or 30 mg flurazepam, 0.25 or 0.50 mg triazolam, or placebo at bedtime, and 250 mg caffeine or placebo in the morning for 2 treatment days. Two objective (Multiple Sleep Latency Test and lapses) and two subjective (Stanford Sleepiness Scale and Visual Analog Scale) measures of sleepiness, five performance tests, and two mood measures (Profile of Mood Scale and Visual Analog Mood Scale) were administered repeatedly on both days. Significant treatment effects were found for sleepiness but not for performance or mood. Early morning caffeine significantly antagonized next day hypnotic-induced drowsiness and enhanced alertness in the subjects who received bed-time placebo. Flurazepam, 30 mg, subjects were more sleepy than all other groups. Although not significantly different, the flurazepam, 30 mg, group demonstrated a trend toward poorer performance and a more negative mood than all other groups. Caffeine most improved performance of this group. In all groups, sleepiness was greatest and performance and mood poorest in early morning trials and caffeine was most effective at this time. Springer-Verlag, 1990 Humans nationallicence Benzodiazepines nationallicence Caffeine nationallicence Sleepiness nationallicence Performance nationallicence Mood nationallicence Johnson L. Naval Health Research Center, P.O. Box 85122, 92138-9174, San Diego, CA, USA aut Spinweber C. University of California at San Diego, San Diego, CA, USA aut Gomez S. Naval Health Research Center, P.O. Box 85122, 92138-9174, San Diego, CA, USA aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 160-167 0033-3158 101:2<160 1990 101 213 https://doi.org/10.1007/BF02244120 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244120 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Johnson L. Naval Health Research Center, P.O. Box 85122, 92138-9174, San Diego, CA, USA aut NATIONALLICENCE 700 1- Spinweber C. University of California at San Diego, San Diego, CA, USA aut NATIONALLICENCE 700 1- Gomez S. Naval Health Research Center, P.O. Box 85122, 92138-9174, San Diego, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 160-167 0033-3158 101:2<160 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer