caa a22 4500 465738435 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244143 doi (NATIONALLICENCE)springer-10.1007/BF02244143 Stereospecific blockade of N-methyl- d -aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning [Elektronische Daten] [M. Morelli, G. Di Chiara] In rats unilaterally lesioned with 6-hydroxydopamine, the D-1 agonist SKF 38393 (3 mg/kg SC) induced contralateral turning only after priming with a dopaminergic agonist such as apomorphine. Administration of the N-methyl-d-aspartate receptor antagonist (+) MK 801 (0.1 mg/kg IP) 15 min before apomorphine (0.1 mg/kg SC) prevented the ability of apomorphine to act as a primer while potentiating its acute contralateral turning effects. The inactive isomer (−) MK 801 was without effect. The results indicate that the N-methyl-d-aspartate receptor exerts a permissive role on priming. Springer-Verlag, 1990 Dopamine nationallicence D-1 receptor nationallicence SKF 38393 nationallicence 6-Hydroxydopamine nationallicence NMDA nationallicence Morelli M. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09100, Cagliari, Italy aut Di Chiara G. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09100, Cagliari, Italy aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 287-288 0033-3158 101:2<287 1990 101 213 https://doi.org/10.1007/BF02244143 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244143 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morelli M. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09100, Cagliari, Italy aut NATIONALLICENCE 700 1- Di Chiara G. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09100, Cagliari, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 287-288 0033-3158 101:2<287 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer