caa a22 4500 465738451 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244129 doi (NATIONALLICENCE)springer-10.1007/BF02244129 Blockade of hoarding in rats by diazepam: an analysis of the anxiety and object value hypotheses of hoarding [Elektronische Daten] [Robert McNamara, Ian Whishaw] The "security hypothesis” suggests food hoarding by rats serves to preempt attack and therefore might be motivated by "anxiety”. The "object value” hypothesis suggests rats hoard objects that they perceive as valuable as related to some state or need. These hypotheses were evaluated with the anxiolytic drug diazepam, which is purported to both decrease anxiety and increase motivation to eat, and which accordingly either may decrease or increase hoarding. Using a new hoarding paradigm, diazepam (Valium: 0.25-5 mg/kg), was found to produce a dose-related reduction in hoarding that was dependent upon food pellet size and that was reversed by flumazenil (Ro 15-1788), a benzodiazepine receptor antagonist. Diazepam also slowed eating speed, blocked "dodging”, a movement used to initiate hoarding, and impaired spatial navigation in a learning-set swimming pool task. The results fail to support the object value hypothesis of hoarding. Since perception of food size, motivation, motor ability and spatial abilities all probably contribute to successful food hoarding, the results provide several explanations other than, or in addition to, anxiety reduction for the drug's effects on hoarding. Nevertheless, the study provides a number of new sensitive measures of the effects of anxiolytic drugs and new insights into their behavioral effects. Springer-Verlag, 1990 Benzodiazepine nationallicence Benzodiazepine and learning nationallicence Benzodiazepine and eating nationallicence Benzodiazepine and food hoarding nationallicence Benzodazepine and rat behavior nationallicence Benzodiazepine and spatial learning nationallicence Food hoarding and anxiety nationallicence Diazepam nationallicence Flumazenil and eating nationallicence Flumazenil and food hoarding nationallicence Flumazenil and rat behavior nationallicence McNamara Robert Department of Psychology, University of Lethbridge, T1K 3M4, Lethbridge, Alberta, Canada aut Whishaw Ian Department of Psychology, University of Lethbridge, T1K 3M4, Lethbridge, Alberta, Canada aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 214-221 0033-3158 101:2<214 1990 101 213 https://doi.org/10.1007/BF02244129 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244129 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McNamara Robert Department of Psychology, University of Lethbridge, T1K 3M4, Lethbridge, Alberta, Canada aut NATIONALLICENCE 700 1- Whishaw Ian Department of Psychology, University of Lethbridge, T1K 3M4, Lethbridge, Alberta, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 214-221 0033-3158 101:2<214 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer