caa a22 4500 46573846X CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244131 doi (NATIONALLICENCE)springer-10.1007/BF02244131 Pharmacokinetic and pharmacodynamic interaction between the antidepressant tianeptine and oxazepam at steady-state [Elektronische Daten] [S. Toon, B. Holt, S. Langley, F. Mullins, M. Rowland, M. Halliday, C. Salvadori, B. Delalleau] To assess if any pharmacokinetic or pharmacodynamic interaction at steady-state occurs between the new antidepressant tianeptine and a benzodiazepine (oxazepam) following multiple oral dosing of both drugs, 12 healthy male volunteers entered a balanced three-way double blind cross-over study. Tianeptine (12.5 mg) and/or oxazepam (10 mg) were given three times daily for 4 days. Pharmacokinetic data within a dosing interval at steady-state showed that there were no statistically significant changes in the pharmacokinetics of either tianeptine (and its two major metabolites) or oxazepam when both drugs were co-administered. Psychometric data showed that there was no synergistic negative interaction between the two drugs and that their combination may result in beneficial effects on "alertness” and "happiness” Springer-Verlag, 1990 Pharmacokinetics nationallicence Pharmacodynamics nationallicence Antidepressants nationallicence Tianeptine nationallicence Oxazepam nationallicence Toon S. Medeval, University of Manchester, M15 4SH, Manchester, UK aut Holt B. Medeval, University of Manchester, M15 4SH, Manchester, UK aut Langley S. Medeval, University of Manchester, M15 4SH, Manchester, UK aut Mullins F. Medeval, University of Manchester, M15 4SH, Manchester, UK aut Rowland M. Department of Pharmacy, University of Manchester, M15 4SH, Manchester, UK aut Halliday M. Department of Psychology, University of Manchester, M15 4SH, Manchester, UK aut Salvadori C. Institut de Recherches Internationales Servier, B.P. 126, F-92202, Neuilly-sur-Seine, France aut Delalleau B. Institut de Recherches Internationales Servier, B.P. 126, F-92202, Neuilly-sur-Seine, France aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 226-232 0033-3158 101:2<226 1990 101 213 https://doi.org/10.1007/BF02244131 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244131 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Toon S. Medeval, University of Manchester, M15 4SH, Manchester, UK aut NATIONALLICENCE 700 1- Holt B. Medeval, University of Manchester, M15 4SH, Manchester, UK aut NATIONALLICENCE 700 1- Langley S. Medeval, University of Manchester, M15 4SH, Manchester, UK aut NATIONALLICENCE 700 1- Mullins F. Medeval, University of Manchester, M15 4SH, Manchester, UK aut NATIONALLICENCE 700 1- Rowland M. Department of Pharmacy, University of Manchester, M15 4SH, Manchester, UK aut NATIONALLICENCE 700 1- Halliday M. Department of Psychology, University of Manchester, M15 4SH, Manchester, UK aut NATIONALLICENCE 700 1- Salvadori C. Institut de Recherches Internationales Servier, B.P. 126, F-92202, Neuilly-sur-Seine, France aut NATIONALLICENCE 700 1- Delalleau B. Institut de Recherches Internationales Servier, B.P. 126, F-92202, Neuilly-sur-Seine, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 226-232 0033-3158 101:2<226 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer