caa a22 4500 465738478 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244133 doi (NATIONALLICENCE)springer-10.1007/BF02244133 Effect of repetitive electroconvulsive treatment on sensitivity to pain and on [3H]nitrendipine binding sites in cortical and hippocampal membranes [Elektronische Daten] [Lucyna Antkiewicz-Michaluk, Jerzy Michaluk, Irena Romańska, Jerzy Vetulani] The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics ofl-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channel density and affinity 24 h after treatment did not differ from the controls; the response to pain was also at the control level. Repeated ECS (eight once-daily shocks) resulted in an increased responsiveness to pain (shortening of response latency) and in an increase in the density of cortical, but not hippocampal, calcium channels. The KD value for [3H]nitrendipine binding sites in either brain region remained unaltered by ECS. The calcium channel antagonist nifedipine, which by itself did not significantly alter the response to pain, prevented the enhancement of pain sensitivity brought about by ECS. The results suggest activation of calcium-dependent mechanisms by repeated ECS and confirm the involvement of calcium channels in pain mechanisms. Springer-Verlag, 1990 Electroconvulsive treatment nationallicence [3H]nitrendipine binding nationallicence Calcium channels nationallicence Hot plate test nationallicence Antkiewicz-Michaluk Lucyna Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL-31-343, Kraków, Poland aut Michaluk Jerzy Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL-31-343, Kraków, Poland aut Romańska Irena Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL-31-343, Kraków, Poland aut Vetulani Jerzy Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL-31-343, Kraków, Poland aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 240-243 0033-3158 101:2<240 1990 101 213 https://doi.org/10.1007/BF02244133 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244133 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Antkiewicz-Michaluk Lucyna Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL-31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Michaluk Jerzy Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL-31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Romańska Irena Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL-31-343, Kraków, Poland aut NATIONALLICENCE 700 1- Vetulani Jerzy Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL-31-343, Kraków, Poland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 240-243 0033-3158 101:2<240 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer