caa a22 4500 465738486 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244138 doi (NATIONALLICENCE)springer-10.1007/BF02244138 Calcium channel blockers: effect on morphine-induced hypermotility [Elektronische Daten] [M. Martin, I. Lizasoain, J. Leza] Acute morphine treatment has been shown to cause a uniform calcium depletion in various brain regions and to evoke hypermotility in mice. On the other hand, it has been reported previously that calcium channel blockers reduce the behavioral stimulation induced by different methods in mice, and it is known that these drugs increase the morphine analgesia and reduce the abstinence syndrome. The effect of calcium channel blockers, nifedipine and diltiazem, on the morphine- and amphetamine-induced hypermotility were evaluated. Mice activity was measured with photocell motility meters. The results show that neither nifedipine nor diltiazem decrease significantly the motility in control and amphetamine-treated mice; however, when they were administered to morphine-treated mice the hypermotility was significantly reduced. The mechanism responsible for this interference is still unknown. Springer-Verlag, 1990 Hypermotility nationallicence Calcium channel blockers nationallicence Nifedipine nationallicence Diltiazem nationallicence Morphine nationallicence Mice nationallicence Martin M. Instituto de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain aut Lizasoain I. Instituto de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain aut Leza J. Instituto de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 267-270 0033-3158 101:2<267 1990 101 213 https://doi.org/10.1007/BF02244138 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244138 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martin M. Instituto de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain aut NATIONALLICENCE 700 1- Lizasoain I. Instituto de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain aut NATIONALLICENCE 700 1- Leza J. Instituto de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 267-270 0033-3158 101:2<267 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer