caa a22 4500 465738494 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244130 doi (NATIONALLICENCE)springer-10.1007/BF02244130 Antinociceptive activity of glycosidic enkephalin analogues [Elektronische Daten] [R. Rodríguez, F. Rodríguez, M. Sacristán, J. Torres, F. Reig, J. García Antón, G. Valencia] The antinociceptive activity of two new enkephalin analogues:N 1.5-(β-d-glucopyranosyl)[d-Met2, Pro5]enkephalinamide andN 1.5-(β-d-galactopyranosyl)[d-Met2, Pro5]enkephalinamide was assessed using the tail immersion and paw pressure behavioural tests. Both enkephalin analogues appear to be more active than morphine when injected either into the fourth ventricle or intrathecally; the galactose analogue is more than 5000 times more active than morphine when injected into the fourth ventricle. The analgesic effects produced by the analogues are partially reversed by SC naloxone (0.1 mg/kg) and totally reversed when the dose of naloxone used was 1 mg/kg, suggesting that the analogues act upon more than one type of opiate receptor (μ/δ). Springer-Verlag, 1990 Enkephalin analogues nationallicence Analgesia nationallicence Fourth nationallicence ventricle nationallicence Intrathecal nationallicence Tail immersion nationallicence Paw pressure nationallicence Rodríguez R. Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Salamanca, E-37002, Salamanca, Spain aut Rodríguez F. Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Salamanca, E-37002, Salamanca, Spain aut Sacristán M. Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Salamanca, E-37002, Salamanca, Spain aut Torres J. Laboratory of Peptides, CSIC, E-08034, Barcelona, Spain aut Reig F. Laboratory of Peptides, CSIC, E-08034, Barcelona, Spain aut García Antón J. Laboratory of Peptides, CSIC, E-08034, Barcelona, Spain aut Valencia G. Laboratory of Peptides, CSIC, E-08034, Barcelona, Spain aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 222-225 0033-3158 101:2<222 1990 101 213 https://doi.org/10.1007/BF02244130 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244130 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rodríguez R. Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Salamanca, E-37002, Salamanca, Spain aut NATIONALLICENCE 700 1- Rodríguez F. Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Salamanca, E-37002, Salamanca, Spain aut NATIONALLICENCE 700 1- Sacristán M. Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Salamanca, E-37002, Salamanca, Spain aut NATIONALLICENCE 700 1- Torres J. Laboratory of Peptides, CSIC, E-08034, Barcelona, Spain aut NATIONALLICENCE 700 1- Reig F. Laboratory of Peptides, CSIC, E-08034, Barcelona, Spain aut NATIONALLICENCE 700 1- García Antón J. Laboratory of Peptides, CSIC, E-08034, Barcelona, Spain aut NATIONALLICENCE 700 1- Valencia G. Laboratory of Peptides, CSIC, E-08034, Barcelona, Spain aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 222-225 0033-3158 101:2<222 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer