caa a22 4500 465738508 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244136 doi (NATIONALLICENCE)springer-10.1007/BF02244136 Pharmacological validation of a novel animal model of anticipatory anxiety in mice [Elektronische Daten] [Alessandro Lecci, Franco Borsini, Giovanna Volterra, Alberto Meli] The current study investigates the action of anxiolytics, antidepressants, neuroleptics, antipyretics, muscle relaxants, antihypertensives and naloxone in a novel animal model of anxiety, based on the evidence that mice removed last from their cage develop hyperthermia (stress-induced hyperthermia, SIH) when compared to those removed first. Alprazolam (0.15-0.6 mg/kg), chlordiazepoxide (25 mg/kg), estazolam (1 mg/kg), phenobarbital (20 mg/kg), ethanol (2 and 4 g/kg), buspirone (5 and 10 mg/kg) and prazosin (1 and 2 mg/kg), as well as repeatedly administered diazepam (5 mg/kg), inhibited SIH. In contrast, tofisopam (12.5-200 mg/kg), desipramine (15 and 30 mg/kg), amitriptyline (10 mg/kg), fluoxetine (10 and 20 mg/kg), tranylcypromine (5 and 10 mg/kg), chlorpromazine (1 and 2 mg/kg), clozapine (2 and 4 mg/kg), pimozide (0.5 and 1 mg/kg),l-sulpiride (15 and 30 mg/kg),l-propranolol (5 and 10 mg/kg), acetyl salicylic acid (200 and 400 mg/kg), indomethacin (2.5 and 5 mg/kg), verapamil (2.5 and 5 mg/kg), captopril (25 and 50 mg/kg), dantrolene (10 and 20 mg/kg), mephenesin (300 and 600 mg/kg),d-amphetamine (1 and 4 mg/kg) and naloxone (2.5 and 15 mg/kg) were inactive, as were 10 mg/kg imipramine, amitriptyline and fluoxetine injected every day for 21 days. Reserpine at high doses (1.25 and 2.5 mg/kg) but not at a lower dose (0.62 mg/kg) prevented SIH, but in this case animals showed a behavioural syndrome which could have interfered with the occurrence of the hyperthermia. Springer-Verlag, 1990 Animal model of anxiety nationallicence Anxiolytics nationallicence Mice nationallicence Temperature nationallicence Stress nationallicence Lecci Alessandro Pharmacological Research Department, "A. Menarini” Pharmaceuticals, Via Sette Santi 3, I-50131, Firenze, Italy aut Borsini Franco Pharmacological Research Department, "A. Menarini” Pharmaceuticals, Via Sette Santi 3, I-50131, Firenze, Italy aut Volterra Giovanna Pharmacological Research Department, "A. Menarini” Pharmaceuticals, Via Sette Santi 3, I-50131, Firenze, Italy aut Meli Alberto Pharmacological Research Department, "A. Menarini” Pharmaceuticals, Via Sette Santi 3, I-50131, Firenze, Italy aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 255-261 0033-3158 101:2<255 1990 101 213 https://doi.org/10.1007/BF02244136 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244136 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lecci Alessandro Pharmacological Research Department, "A. Menarini” Pharmaceuticals, Via Sette Santi 3, I-50131, Firenze, Italy aut NATIONALLICENCE 700 1- Borsini Franco Pharmacological Research Department, "A. Menarini” Pharmaceuticals, Via Sette Santi 3, I-50131, Firenze, Italy aut NATIONALLICENCE 700 1- Volterra Giovanna Pharmacological Research Department, "A. Menarini” Pharmaceuticals, Via Sette Santi 3, I-50131, Firenze, Italy aut NATIONALLICENCE 700 1- Meli Alberto Pharmacological Research Department, "A. Menarini” Pharmaceuticals, Via Sette Santi 3, I-50131, Firenze, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 255-261 0033-3158 101:2<255 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer