caa a22 4500 465738524 CHVBK 20180323111801.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244121 doi (NATIONALLICENCE)springer-10.1007/BF02244121 Effects of chronic administration of ondansetron (GR38032F), a selective 5-HT3 receptor antagonist, on monoamine metabolism in mesolimbic and nigrostriatal dopaminergic neurons and on striatal D2-receptor binding [Elektronische Daten] [Markku Koulu, Jaakko Lappalainen, Jarmo Hietala, Birgitta Sjöholm] The effects of chronic administration of the selective 5-HT3 receptor antagonist ondansetron (GR38032F) on dopamine (DA) and 5-hydrotryptamine (5-HT) metabolism in the major ascending dopaminergic neurons and on striatal D2-receptor binding characteristics were investigated. The metabolism of 5-HT was also studied in a number of other brain areas. Chronic ondansetron (0.2 mg/kg/day and 1.0 mg/kg/day SC for 16 days) did not change DA or 5-HT metabolism in the nigrostriatal or mesolimbic dopaminergic areas, although the larger dose of ondansetron slightly and statistically significantly reduced basal concentrations of DA and 5-HT in the nucleus caudatus. D2-receptor binding characteristics were not affected in the caudateputamen. Ondansetron did not change 5-HT metabolism in the nucleus raphé dorsalis, amygdala, hippocampus or in habenula. It is concluded that chronic administration of ondansetron does not change DA or 5-HT metabolism in the major ascending dopaminergic neurons. This suggest that unlike chronic D2-receptor blockade, chronic blockade of central 5-HT3 receptors does not result in a similar reduction in the activity of nigrostriatal and mesolimbic dopaminergic neurons. Springer-Verlag, 1990 5-HT3 receptors nationallicence GR38032F nationallicence Ondansetron nationallicence Monoamine metabolism nationallicence D2 receptors nationallicence Koulu Markku Department of Pharmacology, University of Turku, Kiinamyllynkatu 10, SF-20520, Turku, Finland aut Lappalainen Jaakko Department of Pharmacology, University of Turku, Kiinamyllynkatu 10, SF-20520, Turku, Finland aut Hietala Jarmo Department of Pharmacology, University of Turku, Kiinamyllynkatu 10, SF-20520, Turku, Finland aut Sjöholm Birgitta Research Centre, Farmos Group Ltd., P.O. Box 425, SF-20101, Turku, Finland aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 168-171 0033-3158 101:2<168 1990 101 213 https://doi.org/10.1007/BF02244121 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244121 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koulu Markku Department of Pharmacology, University of Turku, Kiinamyllynkatu 10, SF-20520, Turku, Finland aut NATIONALLICENCE 700 1- Lappalainen Jaakko Department of Pharmacology, University of Turku, Kiinamyllynkatu 10, SF-20520, Turku, Finland aut NATIONALLICENCE 700 1- Hietala Jarmo Department of Pharmacology, University of Turku, Kiinamyllynkatu 10, SF-20520, Turku, Finland aut NATIONALLICENCE 700 1- Sjöholm Birgitta Research Centre, Farmos Group Ltd., P.O. Box 425, SF-20101, Turku, Finland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 168-171 0033-3158 101:2<168 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer