caa a22 4500 465738540 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244135 doi (NATIONALLICENCE)springer-10.1007/BF02244135 Lavie Peretz Sleep Laboratory, Faculty of Medicine, Technion — Israel Institute of Technology, 32000, Haifa, Israel aut Effects of midazolam on sleep disturbances associated with westward and eastward flights: Evidence for directional effects [Elektronische Daten] [Peretz Lavie] This double-blind parallel groups study investigated the effects of 7.5 mg midazolam on transient insomnia caused by eastward and westward multiple time zone flights. Three groups of six subjects each were treated with either midazolam or placebo during the first four post-flight nights in both directions. Sleep-wake behavior was monitored throughout the study by actigraphic recordings from the wrist of the non-dominant hand in 1 min bins and by morning questionnaires. The results showed that midazolam significantly lengthened sleep and increased the percentages of bins defined as sleep after the eastward flight. These results are discussed in view of recent findings that short-acting benzodiazepines induced phase shifts in mammalian circadian rhythms. Springer-Verlag, 1990 Midazolam nationallicence Jet-lag nationallicence Sleep-wake nationallicence Actigraph nationallicence Psychopharmacology Springer-Verlag 101/2(1990-06-01), 250-254 0033-3158 101:2<250 1990 101 213 https://doi.org/10.1007/BF02244135 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244135 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lavie Peretz Sleep Laboratory, Faculty of Medicine, Technion — Israel Institute of Technology, 32000, Haifa, Israel aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 250-254 0033-3158 101:2<250 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer