caa a22 4500 465738559 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244141 doi (NATIONALLICENCE)springer-10.1007/BF02244141 Naloxone induces miosis in normal subjects [Elektronische Daten] [Norbert Loimer, Rainer Schmid, Josef Grünberger, Leo Linzmayer] In a placebo-controlled trial, pupillary constriction was measured in healthy non-addicted subjects and in opiate addicts by using static computer-assisted pupillometry. In contrast to earlier reports, a clear-cut pupillary constriction was observed in healthy persons after a single intravenous injection of 0.4 mg naloxone. No significant changes of pupillary size were recorded in the same subjects after the administration of a placebo. In methadone-maintained subjects, the IV administration of 0.4 mg naloxone caused a significant pupillary dilatation. From these data it can be concluded that naloxone seems to have a central pharmacological action not only in opiate addicts, but also in healthy persons. This is demonstrable by studying the miotic response. Springer-Verlag, 1990 Naloxone nationallicence Pupillary changes nationallicence Pharmacological action nationallicence Loimer Norbert Psychiatrische Universitätsklinik Wien, Waehringer Guertel 18-20, A-1090, Vienna, Austria aut Schmid Rainer Psychiatrische Universitätsklinik Wien, Waehringer Guertel 18-20, A-1090, Vienna, Austria aut Grünberger Josef Psychiatrische Universitätsklinik Wien, Waehringer Guertel 18-20, A-1090, Vienna, Austria aut Linzmayer Leo Psychiatrische Universitätsklinik Wien, Waehringer Guertel 18-20, A-1090, Vienna, Austria aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 282-283 0033-3158 101:2<282 1990 101 213 https://doi.org/10.1007/BF02244141 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244141 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Loimer Norbert Psychiatrische Universitätsklinik Wien, Waehringer Guertel 18-20, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Schmid Rainer Psychiatrische Universitätsklinik Wien, Waehringer Guertel 18-20, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Grünberger Josef Psychiatrische Universitätsklinik Wien, Waehringer Guertel 18-20, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Linzmayer Leo Psychiatrische Universitätsklinik Wien, Waehringer Guertel 18-20, A-1090, Vienna, Austria aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 282-283 0033-3158 101:2<282 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer